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BAP-1兔單克隆抗體

BAP-1兔單克隆抗體

  • 價(jià)格￥2200
  • 規(guī)格100ul
  • 貨號(hào)HKZ150401
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150401BAP-1兔單克隆抗體100ul支2200
BAP-1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50278?Clone# ?BP6255
Predicted?Molecular Wt:
80kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q92560
Background:
BAP-1?(BRCA-1 Associated?Protein-1)?is?an?80?kDa?protein?known?to?function?as?a?deubiquitinase?(DUB);?removing?ubiquitin modifiers, which alter the function of other?proteins?via?targeted?degradation,?subcellular?localization,?or?activity.?By
removing?ubiquitin,?BAP-1?helps?regulate the function of target?proteins?involved?in?diverse cellular?processes.
BAP-1 was ?expressed?in?most?normal cells,?but deletion?of?expression?has?been?found?in?mesothelioma.
Germline?mutations?in the?BAP-1 gene?have?been associated with?BAP-1 tumor?predisposition syndrome,?a?condition?linked?to?early onset and/or?increased?risk of?multiple types of?cancers?including?uveal?melanoma,?malignant?mesothelioma,?cutaneous??melanoma, and?renal cell?carcinoma.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Citterio?E. ?Front?Genet.?2015;?6:282.
2. ?Murali?R, Wiesner?T, Scolyer?RA.?Pathology.?2013?Feb;?45(2):116-26.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-???embedded?sections)?analysis of human?mesothelioma?labelling?BAP-1 with?BP6255.?

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