一抗 抗體 試劑 PMS2兔單克隆抗體一抗 抗體 試劑 價格¥2200規(guī)格100ul貨號HKZ150235單位支品牌HaoKebio QQ53383090 咨詢購買 產(chǎn)品介紹產(chǎn)品參數(shù)資料下載 品牌商品編碼商品名稱規(guī)格單位單價HaoKebioHKZ150235PMS2兔單克隆抗體100ul支2200PMS2Recombinant?Rabbit?Monoclonal Antibody?Product?DatasheetCatalog# ?BX50112?Clone# ?BP6116Predicted?Molecular Wt:96kDaPurity: ??ProA?affinity?purified?IgGSpecies Cross-reactivity:HumanForm: ??LiquidApplications:IHC-PSwissprot?ID: ??P54278Background:Mismatch?repair?(MMR)?proteins?is a group of?nuclear enzymes,?which?in?all?proliferating?cells?participate?in?repair?of?base-base?mismatch, that occur?during?DNA?replication.?Loss of?MMR?proteins?leads to an?accumulation?of?DNA?replication?errors?in?the?proliferating cells,?particularly?in areas of the genome with?short?repetitive?nucleotide?sequences,?a?phenomenon?known?????as?microsatellite?instability?(MSI).The?PMS2?protein forms a?heterodimer with the?MLH1?protein which?is then?activated?in the?presence?of ATP;?this?complex???coordinates the?binding of other?proteins that?repair?DNA errors arising?during?cell?preparation?for?cell?division.?The?loss?of?????PMS2 expression?in tumors can?be?helpful?in?identifying?hMLH1?mutation carriers and?identifies?their?suitability?for?mutationanalysis.?PMS2 gene defects account for a?small?but?significant?proportion?of?colorectal?cancers?and?for?a?substantial?proportion of tumors with?microsatellite?instability.Compared to?molecular?biological techniques,?immunohistochemical analysis of?MMR?protein expression?is?much?simpler?and?cheaper.?Immunohistochemical analysis?helps to?pinpoint the affected gene and?should?be?readily?accessible?in?a?pathologylaboratory.Subcellular?location:NucleusRecommended?method:Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.Immunogen:Synthetic?peptide corresponding to?residues within?aa1-100 of?PMS2 was?used?as?an?immunogen.Storage?Buffer:PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.Storage conditions:-25°C?to?-18°CStorage instructions:Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.Recommended?Dilutions:IHC-P:?????1:100-1:200Background?References:1.?Shia?J, Virchows?Arch.?2004?Nov;445(5):431-41.?Epub2004 Sep?29.2.?Wright?CL, Am?J?Surg?Pathol.?2003?Nov;27(11):1393-?406.Immunohistochemistry?(Formalin/PFA-fixedparaffin-embeddedsections)?analysis ofesophagus?labellingPMS2 with?BP6116.?Heat mediated?antigenretrieval was?performed?using Tris/EDTA?buffer????pH?9.0. HKZ150235_BP6116_PMS2下載 暫無 說明文檔下載說明書.pdf 上一篇: Cytokeratin (HMW)兔單克隆抗體Cocktail下一篇: GCDFP-15兔單克隆抗體 推薦 TTC染液(0.1%,植物) 2024年10月25日 1491 暫無 查看全文 Synaptophysin兔單克隆抗體 2024年5月21日 898 暫無 查看全文 COL4A3兔單克隆抗體 2024年5月23日 890 暫無 查看全文 TBR1鼠單克隆抗體 2023年7月14日 697 Tested Applications: IF, IHC, WB,ELISA Cited Applications: IF, IHC 、 Species Specificity: Human, r... 查看全文 您好!請登錄 點擊取消回復(fù) 請登錄后評論 點擊這里取消回復(fù)。
TBR1鼠單克隆抗體 2023年7月14日 697 Tested Applications: IF, IHC, WB,ELISA Cited Applications: IF, IHC 、 Species Specificity: Human, r... 查看全文
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