CA125兔單克隆抗體

價格￥1000
規(guī)格100ul
貨號HKZ150132
單位支
品牌HaoKebio

產品介紹

產品參數(shù)

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品牌	商品編碼	商品名稱	規(guī)格	單位	單價
HaoKebio	HKZ150132	CA125兔單克隆抗體	100ul	支	1000

CA125
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# BX50009?Clone# ?BP6014
?
Predicted?Molecular Wt:
1519kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q8WXI7

Background:
CA125?(cancer?antigen?125,carcinoma?antigen?125, or?carbohydrate?antigen?125)?also?known?as?mucin?16,??is?a?member?of?the
mucin family glycoproteins. CA125?is a component?of the?ocular?surface?(including?the?cornea?and?conjunctiva),?the
respiratory tract and the female?reproductive tract epithelia.?Since?CA125?is?highly glycosylated?it?creates?a?hydrophilic???environment that acts as a?lubricating?barrier against?foreign?particles?and?infectious?agents?on?the?apical?membrane?of?epithelial cells.
CA125?reacts with?both?normal tissues and?neoplasms of fallopian tube, endometrium,?endocervix?and?mesothelioma.?It?does???not?react with colon cancer.?Normal tissues such?as?breast,?liver,?skin,?kidney?and?spleen?are?also?negative.?Studies?have?shown?that CA125?reacts with approximately 80% of?epithelial?ovarian?neoplasms?of?serous,?endometrioid,?clear?cell?and
undifferentiated types.?No?reactivity?has?been shown for?mucinous ovarian tumors or?in?germ?cell?or?hematopoietic?tumors.
This antibody?is a?useful aid for classification?of?a?variety?of tumors,?such?as?some?adenocarcinomas?of the?colon,?breast?carcinomas,?malignant?mesothelioma,?uterine adenomatoid tumor,?lung?bronchoalveolar carcinoma, and?ovarian
endometrioid and serous?carcinomas.
?

Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to CA125?residues?within?aa12201‐12300 of?CA125?was?used?as?an
immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Prat?A., et?al. Ann?Oncol.?2008?Feb;19(2):327-31.
?
2.?Tornos?C., et?al. Am?J?Surg?Pathol.?2005?Nov;29(11):1482-9.