CD3D兔單克隆抗體

價格￥600
規(guī)格100ul
貨號HKZ150423
單位支
品牌HaoKebio

產(chǎn)品介紹

產(chǎn)品參數(shù)

資料下載

品牌	商品編碼	商品名稱	規(guī)格	單位	單價
HaoKebio	HKZ150423	CD3D兔單克隆抗體	100ul	支	600

CD3D
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50300?Clone# ?BP6277
Predicted?Molecular Wt:
19kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P04234
Background:
When T cells encounter antigens via the T?cell?receptor?(TCR),?information?about the?quantity?and?quality?of?antigens?is?relayed to the?intracellular signal transduction?machinery. This activation?process depends?mainly?on?CD3?(Cluster?of
Differentiation?3),a?multiunit?protein complex that directly associates with the?TCR.?CD3?is?composed?of four?polypeptides:?ζ,?γ, ε(CD3E), and?δ?(CD3D).?Each?of?these?polypeptides?contains?at?least?one?immunoreceptor?tyrosine-based?activation?motif
(ITAM).?Engagement of the TCR complex with foreign?antigens?induces tyrosine?phosphorylation?in the?ITAM?motifs?and
phosphorylated?ITAMs function as docking sites for?signaling?molecules such?as?ZAP-70?and?the?p85?subunit?of?PI-3?kinase.
TCR?ligation also?induces a conformational change?in?CD3D,?such?that?a?proline?region?is?exposed?and?then?associates?with?the?adaptor?protein?Nck.
CD3D?is generally expressed?in T cells and their?source?tumor?cells.
Defects?in CD3D area cause of severe?combined?immunodeficiency?autosomal?recessive?T-cell-negative/B-cell-positive/NK-?cell-positive?(T(-)/B(+)/NK(+) SCID).
Subcellular?location:
Membrane
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer: ?
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA
0.05%.????????????????????????????????????????????????????????????????????????????????????????????????
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?Kuhns,?M.S.?et?al.?(2006)?Immunity?24,?133-139.
2. ?Pitcher,?L.A. and?van?Oers,?N.S.?(2003)?Trends?Immunol.?24,?554-?560.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded
sections)?analysis?of??human?tonsil?labelling?CD3D?with?BP6277.

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