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CXCR5兔單克隆抗體

CXCR5兔單克隆抗體

  • 價格￥2200
  • 規(guī)格100ul
  • 貨號HKZ150385
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150385CXCR5兔單克隆抗體100ul支2200
CXCR5
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50262?Clone# ?BP6239
Predicted?Molecular Wt:
42kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P32302
Background:
Initially?discovered?in?1992 as?Burkitt’slymphoma?receptor?1, CXCR5?(also?known?as?CD185)?is?a?seven-transmembrane?G
protein-coupled?receptor?(GPCR)?protein, which?plays fundamental?roles?in?inflammatory,?infectious and?immune?responses.
CXCR5?is expressed?in?mature?B-cells and?Burkitt’s?lymphoma. CXCR5?is?highly expressed?in?primary?and?secondary?follicles
within gastric?lymphomas.?Higher CXCR5 expression and?migration?by?non-small?cell?lung?cancer?(NSCLC)?cells?suggest?a?role?in
migration?and?metastasis?of?primary?lung?tumors?in?response?to?CXCL13.?It?has?been?proposed?that?CXCR5/CXCL13,?either
alone or?in combination, could?be?used as?a?prognostic?biomarker?for?lung?cancer.?Other?studies?have?shown?that?CXCR5
overexpression?in?breast cancer?patients?highly correlates with?lymph?node?metastases, and?elevated?CXCR5?antibody
expression?may contribute to abnormal cell survival?and?migration?in?breast?tumors?that?lack?functional?p53?protein.?Another?study?has?indicated that?prostate cancer tissue as well as?cell?lines?express?higher?non-basal?levels?of?CXCR5?and?found?a
correlation?between the?level of CXCR5 and Gleason?score.?CXCR5?location?was?additionally?considered?and?higher?Gleason?scores correlated with?nuclear CXCR5 while cytoplasmic?and?membrane?CXCR5?correlated?with?benign?and?early?prostate????cancers.
Subcellular?location:
Membrane/cytoplasm
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?LennikovA, et?al.?Lab?Invest.?2021?Feb;101(2):228-244.
2.?Tan?P, et?al.?Precision?Clinical?Medicine, Volume?1,?Issue?1, June?2018,?Pages?49–56
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of tonsil?labelling CXCR5 with?BP6239.

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