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CGATA-3兔單克隆抗體

GATA-3兔單克隆抗體

  • 價格￥1000
  • 規(guī)格100ul
  • 貨號HKZ150375
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150375GATA-3兔單克隆抗體100ul支1000
GATA-3
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50252?Clone# ?BP6229
Predicted?Molecular Wt:
48kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P23771
Background:
GATA?binding?protein?3 or GATA-3,?is a zinc finger?transcription?factor?and?plays?an?important?role?in?promoting?and?directing?cell?proliferation, development, and differentiation?in?many tissues?and?cell?types.
GATA-3?is?one?of?the?three?genes?mutated?in?10% of?breast?cancers.?Nuclear?expression?of?GATA-3?in?breast?cancer?is
considered a?marker of?luminal cancer?in?ER+ cancer?and?luminalandrogen?responsive?cancer?in?ER-/AR+ tumors.?It?is?highly?coexpressed with?FOXA1 and serves as?negative?predictor?of?basal?subtype?and?HER-2?and?is?also?considered?a?strong
predictor of taxane and?platin salts?insensitivity.
GATA-3 expression?is found?in?urothelial carcinoma, especially?in?invasive and?high?grade?tumors.?Therefore,?GATA-3?can?be
used?in a?panel of antibodies for diagnosis?of?unknown?primary?carcinoma,?when?carcinomas?of the?breast?or?bladder?area
possibility. Studies?have also shown the?utility of?GATA-3?in?differntiatingurothelial?carcinoma?from?prostate?adenocarcinoma?and squamous cell carcinomas of the?uterine,?cervix,?anus?and?lung.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Voduc?D, et?al.?Cancer?Epidemiol?Biomarkers?Prev.
2008?Feb;17(2):365-73.
2. ?Miettinen?M, et?al. Am?J?Surg?Pathol.?2014 Jan;?38(1):?13–22.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of ?invasive?ductal carcinoma?of?the?breast?labelling?GATA-3 with?BP6229.

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