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ROR gamma T兔單克隆抗體

ROR gamma T兔單克隆抗體

  • 價(jià)格￥2200
  • 規(guī)格100ul
  • 貨號(hào)HKZ150379
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150379ROR gamma T兔單克隆抗體100ul支2200
ROR?gamma?T
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50256?Clone# ?BP6233
Predicted?Molecular Wt:
55kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P51449-2
Background:
Retina-associated orphan?receptors?(RORs) contains ?three subtypes:?RORα,?RORβ,and?RORγ?. ?They?are widely?distributed?in
body tissues, and?most of them can?directly?enter the?nucleus to?regulate the?transcription?of?target?genes,?thus?showing?different tissue specificity and?participating?in?different?physiological?processes. ?In?particular,?RORα?and?RORγ?play?an
important?role?in?mediating?Th17 cell?differentiation. ?RORγ?can?be?divided?into?RORγ1?and?RORγ2?(RORγ T),?which?show different tissue specificity.
ROR?Gamma?(T)?is?expressed?only?in?lymphoid?compartment?cells,?i.e.,?CD4+CD8+?“double?positive”?thymocytes,?peripheral Th17 cells, and?lymphoid tissue?inducer?(LTi) cells of?lymphoid?organs.
At?present,?RORγ T?is considered as a?new target for?drug?development?against?autoimmune?diseases,?especially?psoriasis.?In
recent years,?RORγ T small?molecule?inhibitors?have?become a?hot?research field?in academia?and?even?international?pharmaceutical companies, with great development?potential.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?ROR gamma T was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Ouyang?W??etal.?Invest?Ophthalmol?Vis?Sci?62:25?(2021).
2.?Zhang?Y??et?al.?Exp?Ther?Med?21:483?(2021).
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of tonsil?labelling?ROR gamma?T?with?BP6233.

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