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MHC Ⅰ兔單克隆抗體

MHC Ⅰ兔單克隆抗體

  • 價格￥1800
  • 規(guī)格100ul
  • 貨號HKZ150380
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150380MHC Ⅰ兔單克隆抗體100ul支1800
MHC?Ⅰ
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50257?Clone# ?BP6234
Predicted?Molecular Wt:
40/41kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P04439/P01889/P10321
Background:
Major?Histocompatibility?Complex?(MHC)?is a genetic?region on chromosomes?composed?of tightly?linked?highly?polymorphic?gene?loci that encode cell surface specific?proteins,?depending?on?the?structure?and?function?of genes?and?coding?products.
We?divide?MHC?into?class??Ⅰ,?class?Ⅱ and?class?Ⅲ gene?regions.??Endogenous?antigen?presentation?is?presented?by?the?major histocompatibility?complex??Ⅰ (MHC??Ⅰ)?pathway.??Intracytoplasmic?proteins?are?decomposed?into?peptides?during?protease ??degradation, which?in turn are delivered?by?HSP41 and?HSP90?proteins?to TAP?on?the?membrane.
MHC?Ⅰ is widely?distributed on the surface of?almost?all?nucleated?cells,?including?spleen,?lymph?nodes?and?thymus
lymphocytes?in?normal tissues. ?It?is also?expressed?in?skin,?lung,?kidney,?liver?and?heart tissues.??It?is?also?widely?expressed?in?tumor tissues.
MHC ?Ⅰmolecular typing?is?related to the?matching of?organ?transplantation?and?bone?marrow?transplantation,?as?well?as?a?variety of autoimmune?diseases.
?Subcellular?location:
Membrane
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?HLA-A was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Wang?K??et?al.?Mol?Med?Rep?22:2052-2062?(2020).
2. ?Klein?S??et?al.?Cancer?Immunol?Immunother?68:973-982?(2019).
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis?of?tonsil?labelling?MHC?Ⅰ with BP6234.

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