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NUT1兔單克隆抗體

NUT1兔單克隆抗體

  • 價(jià)格￥1800
  • 規(guī)格100ul
  • 貨號HKZ150367
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150367NUT1兔單克隆抗體100ul支1800
NUT1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50244?Clone# ?BP6221
Predicted?Molecular Wt:
120kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q86Y26
Background:
Nuclear?protein?in?testis?(NUT1 or?NUTM1)?is?a?nuclear?protein?encoded?by?the?NUTM1?gene?on?chromosome?15?and?normally expressed?in testicular tissues.?NUT1?is an?unstructured?protein with few orthologs,?and?shuttles?between?the?nucleus?and
cytoplasm.?NUT cancer?(formerly?NUT?Midline Carcinoma) occurs after?a?gene fusion?event?between?NUTM1?and?often?a
bromodomain?(BRD) family?gene?in?about?75% of?cases.?NUTM1?less?commonly?fuses?with?NSD3,?MXD4,?MGA,?ZNF532,?CIC,?and other?rare variants, which are all?considered?to?be?NUT?cancers.
NUT cancers can?be carcinomas, sarcomas,?lymphomas,?and?other types?of tumors,?and?are?often?formed?in?the?head,?neck,?or?mediastinum.?However,?primary cancers?have?been?reported?in?kidney,?bladder,?lung,?breast, and?metastasis to?lymph?nodes????has also?been seen for these very?aggressive?tumors.
NUT1 antibody?is?mainly?used?in the diagnosis of?midline carcinoma.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?residues of?NUT1?was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?French,?C.A.?et?al.?(2003) Cancer?Res?63,?304-7.
2. ?Haack,?H. et?al.?(2009) Am?J?Surg?Pathol?33,?984-91.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of testis?labelling?NUT1 with?BP6221.

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