一抗 抗體 試劑 PD-L1兔單克隆抗體一抗 抗體 試劑 價(jià)格¥2200規(guī)格100ul貨號(hào)HKZ150260單位支品牌HaoKebio QQ53383090 咨詢購買 產(chǎn)品介紹產(chǎn)品參數(shù)資料下載 品牌商品編碼商品名稱規(guī)格單位單價(jià)HaoKebioHKZ150260PD-L1兔單克隆抗體100ul支2200PD-L1Recombinant?Rabbit?Monoclonal Antibody?Product?DatasheetCatalog# ?BX50137?Clone# ?BP6141Predicted?Molecular Wt:33kDaPurity: ??ProA?affinity?purified?IgGSpecies Cross-reactivity:HumanForm: ??LiquidApplications:IHC-PSwissprot?ID:??Q9NZQ7Background:Programmed?cell?death?ligand?1?(PD-L1) also?known?as?cluster?of?differentiation?274?(CD274)?or?B7?homolog?1?(B7-H1)?is?a?type?1?transmembrane?protein?involved?in the?regulation of cellular and?humoral?immune?responses. The?interaction?of?PD-L1 with?its???receptor?PD-1?provides?both stimulatory and?inhibitory signals?in?regulating T cell?activation?and?tolerance?during?pregnancytissue allografts, autoimmune disease and?malignant transformation.PD-L1?is?expressed?on?resting?T?cells,?B?cells,?DCs,?and?macrophages?and?is?further?up-regulated?upon?activation.?PD-L1?is?alsoexpressed on?parenchymal cells,?including vascular endothelial?cells and?pancreatic?islet?cells.?The?expression?of?PD-L1?has?been????discovered?in avariety of epithelial cancers?such?as?non-small?cell?lung?carcinoma?(NSCLC),?pancreatic?cancer,?esophageal?cancer,?squamous cell carcinomas of the?head and?neck,?and?renal?cell?carcinoma?(RCC).The?use of?IHC for?protein?identification, along with?novel therapies, such?as?checkpoint?inhibitors?and?vaccines,?are?generating?new options for the treatment of?cancer?patients.Subcellular?location:MembraneRecommended?method:Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.Immunogen:Recombinant full?length?protein corresponding toHuman?PD-L1?(extracellular). The?immunogen?contains the?specific?extracellular?domain?of?huPD-L1?(F19-T239).Storage?Buffer:PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.Storage conditions:-25°C?to?-18°CStorage instructions:Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.Recommended?Dilutions:IHC-P:?????1:100-1:200Background?References:1. ?MuenstS1, et?al.?Breast?Cancer?Res?Treat.?2014?Jul;146(1):15-24.2. ?Lim?SH, et?al.?Expert?Opin?Biol?Ther.?2016;16(3):397-?406.Immunohistochemistry(Formalin/PFA-fixedparaffin-embeddedsections analysis?ofplacenta tissue?labellingPD-L1 with?BP6001.?Heat ???mediated?antigen?retrieval?was?performed?usingTris/EDTA?buffer?pH?9.0 HKZ150260_BP6141_PDL1下載 暫無 說明文檔下載說明書.pdf 上一篇: PAX-5兔單克隆抗體下一篇: Desmin兔單克隆抗體 推薦 GORASP2兔多克隆抗體 2024年10月11日 1048 暫無 查看全文 CD19兔單克隆抗體 2023年7月14日 589 Tested Applications: FC, IHC, WB,ELISA Cited Applications: IHC, WB Species Specificity: human Cited S... 查看全文 SOX2兔單克隆抗體 2024年5月22日 825 暫無 查看全文 防熒光衰減封片劑 2024年11月8日 1514 暫無 查看全文 您好!請(qǐng)登錄 點(diǎn)擊取消回復(fù) 請(qǐng)登錄后評(píng)論 點(diǎn)擊這里取消回復(fù)。
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