CD5兔單克隆抗體

價(jià)格￥600
規(guī)格100ul
貨號(hào)HKZ150208
單位支
品牌HaoKebio

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產(chǎn)品參數(shù)

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品牌	商品編碼	商品名稱	規(guī)格	單位	單價(jià)
HaoKebio	HKZ150208	CD5兔單克隆抗體	100ul	支	600

CD5
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50085?Clone# ?BP6090
Predicted?Molecular Wt:
55kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P06127
Background:
The CD5 antigen?is a transmembrane glycoprotein?expressed?on the?surface?of?practically?all?mature?human?T-cells?(about?10%
of?CD4+ T-cells?being?CD5?negative).?In?immature?(CD34+) T-cells, CD5?is?weakly?expressed, the?intensity?of?expression
increaing?with?maturation.?CD5?is?also?expressed?in?a?small?subset?of?normal?human?B-cells?(20%?of?B-cells?in?the?peripheral
blood, scattered cells?in the?lymph?node?mantle zone). The?CD5+?cells?are?probably?involved?in?B-T?interaction?and their?ligand?is?CD72 which?is?expressed?on?all?B?cells.?It?appears?that?CD5+?B-cells?on?activation?primarily?produce?IgM. They?also?produce ???moreautoantibodies than?normal CD5?negative?B-cells. Thus, the CD5+?B-cell?population?is expanded?in?rheumatoid?arthrititis?and systemic?lupus erythematosus.
The CD5 antibody?reacts with?CD5 expressed?on?B?and T?cells,??and?may?be?a?useful?aid for?theclassification?of?B?and?T-cell
malignancies. This?includes?B-cell?chronic?lymphoid?leukemia?(B-CLL),?B-cell?small?lymphocytic?lymphoma?(B-SLL),?mantle?cell lymphoma?(MCL) and T-cell?lymphoma and?leukemia.Subcellular?location:
Cytomembrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant full?length?protein corresponding to
Human?CD5?(extracellular). The?immunogen contains
the?specific?extracellular?domain?of?huCD5?(D32-P372)
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Gloria?Soldevila, et?al. J?Leukoc?Biol.?2019;1-14.
2.??Manjun?Zhao,?Ningning?Duan,et?al. Autoimmunity.2019;1-9.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of
appendix tissue?labelling?CD5 with?BP6090.?Heat ???mediated?antigen
retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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