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Cyclin D1兔單克隆抗體

Cyclin D1兔單克隆抗體

  • 價(jià)格￥1000
  • 規(guī)格100ul
  • 貨號(hào)HKZ150194
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150194Cyclin D1兔單克隆抗體100ul支1000
Cyclin?D1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50071?Clone# ?BP6076
Predicted?Molecular Wt:
34kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P24385
Background:
Cyclin?D1?(synonymes:?PRAD1,?parathyroid?adenomatosis?1,CCND1) is?a?295 amino?acid?protein,?36?kDa,?which?belongs?to?the
highly conserved cyclin family, whose?members are?characterized?by?a?dramatic?periodicity?in?protein?abundance throughout?the cell cycle. Cyclin?D1 forms a?complex?with?and?functions?as?a?regulatory?subunit?of?CDK4?or?CDK6,?whose?activity?is
required for cell cycle G1/S transition. The?protein?has?been?shown to?interact?with?tumour?suppressor?protein?Rb?andits?expression?is?regulated?positively?by?Rb.
The expression?is cell cycle dependant,?maximal?in?G1?and?minimal?in?S?phase.?Localization?is?mainly?nuclear.?In?normal tissues,?Cyclin?D1 expression?is?restricted to the?proliferative zone of epithelial?tissues,?endothelium?and?some?fibroblasts.?There?is?no???expression?in?lymphoid tissue.
Mutations with amplification of the cyclin?D1 gene,?with?overexpression?of the?protein,?which?alters?cell?cycle?progression,?are?observed frequently?in a variety of tumours and?may?contribute?to?tumourigenesis.
In?diagnostic?pathology,?immunohistochemical detection of Cyclin?D1?is?used?mainly for the?diagnosis?of?mantle?cell
lymphoma. While other?methods of cyclin?D1 detection?are?being?explored,?immunohistochemistry?is?still?widely?used?and?anti-cyclin?D1 antibodies?remain an essential component?in?a?small?B-cell?lymphoproliferative?disorder?panel.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?residues within???aa200-295 of??Cyclin?D1 was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Hirai,?H. et?al.?Novel?INK4?proteins,?p19 and?p18,are?specific ?inhibitors of the cyclin?D-dependent?kinases CDK4 and?CDK6.?Mol?Cell?Biol.?1995?May;?15(5):?2672–2681.
2.?Sherr,?C.J.?Cancer?cell?cycles. Science.?1996?Dec 6;274(5293):1672-7.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections?analysis of
mantle?cell?lymphoma????labelling Cyclin?D1?with??BP6076.?Heat?mediated antigen?retrieval?was
performed?using
Tris/EDTA?buffer?pH?9.0.

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