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p120兔單克隆抗體

p120兔單克隆抗體

  • 價格￥1000
  • 規(guī)格100ul
  • 貨號HKZ150193
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150193p120兔單克隆抗體100ul支1000
p120
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50070?Clone# ?BP6075
Predicted?Molecular Wt:
108kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??O60716
Background:
Alpha-catenin and?beta-catenin?bind to the?intracellular domain of?E-cadherin?while?p120?catenin?binds?E-cadherin?at?a juxta-?membrane site. The complex stabilizes tight junctions.?In the cell,?p120?catenin?localized?to?the?E-cadherin/catenins?cell
adhesion complex, directly associates with?cytoplasmic?C-terminus?of?E-cadherin?and?may?similarly?interact with?other?cadherins.
p120?is a?proliferation-associated?nucleolar?protein found?in?most?human?malignant tumors,?but?not?in?resting?normal cells.?In?colorectal cancer the altered?localization of?p120 catenin?corresponds?with?loss?of?cytoplasmic?localization?of?E-cadherin.
Studies?have shown accurate categorization of?ductalvs.?lobular?neoplasia?in the?breast?was?achieved?with?p120?staining.?p120 expression further clarifies the separation?of?low-grade?ductal?carcinoma?in?situ from?lobular?neoplasia.?Studies?also?have shown that altered expression?of?p120 catenin?antibody?predicts?poor?outcome?in?invasive?breast?cancer.
Subcellular?location:
Cytoplasm and?membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?p120?residues?within?aa900-1000 of??p120 was?used?as?an
immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Talvinen?K, et?al. Altered?expression?of?p120 catenin predicts?poor outcome?in?invasive?breast cancer. J?????Cancer?Res?Clin?Oncol.?2010 Sep;?136(9):1377-87.
?2.?Chivukula?M, et al.?Pleomorphic?lobular carcinoma?in
situ?(PLCIS) on?breast core?needle?biopsies: clinical
significance?and?immunoprofile. Am?J?Surg?Pathol.?2008?Nov; 32(11):1721-6.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections?analysis of?colon?tissue?labelling?p120 with BP6075.?Heat?mediated ???antigen?retrieval was
performed?using
Tris/EDTA?buffer?pH?9.0

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