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E-Cadherin兔單克隆抗體

E-Cadherin兔單克隆抗體

  • 價(jià)格￥600
  • 規(guī)格100ul
  • 貨號(hào)HKZ150166
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150166E-Cadherin兔單克隆抗體100ul支600
E-Cadherin
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50043?Clone# ?BP6048
Predicted?Molecular Wt:
97kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P12830
Background:
E-cadherin?is a transmembrane, calcium dependent cell?adhesion?protein?that?mediates?cell?to?cell?adhesion?and?maintains?structural and functional?integrity of epithelial tissues.?It?also?has?pivotal?barrier functions?and?maintains?the?polarity?of
epithelial cells.?Reduced or aberrant?E-cadherin expression?breaks?cell to?cell?contacts,?and?thus,?cells?acquire?the?ability?to?migrate.
In?normal tissues,?immunostaining of?E-cadherin?is?localized to the?membrane of epithelial?cells,?consistent?with?its?role?in?cell?adhesion. And?in tumor tissues,?E-cadherin stains?positively?in glandular epithelium?as?well?as?adenocarcinomas?of the?lung,?????gastrointestinal tract, and ovary.?It?has also?been?shown to?be?positive?in?some thyroid?carcinomas.
A combination of?E-cadherin and?p120 catenin?may?help?distinguish?ductal?carcinoma?of the?breast?from?lobular?carcinoma.????And also, several studies?have?reported that?reduced?E-cadherin expression?is?correlated?with?poor?prognosis?in?several?types?of carcinomas.
Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?E-Cadherin
residues?within?aa600-700 of?E-cadherin?was?used?as an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Xie?Y, et?al. Oncotarget.?2017 Aug?4;8(37):62489-62499.
2. ?F. van?Roy,?et?al.?Cell?Mol?Life?Sci.?2008?Nov;65(23):3756-88.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections?analysis of?liver?tissue?labelling??E-
Cadherin?with?BP6048.????Heat?mediated?antigen???retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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