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Bcl-6兔單克隆抗體

Bcl-6兔單克隆抗體

  • 價(jià)格￥1000
  • 規(guī)格100ul
  • 貨號(hào)HKZ150407
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150407Bcl-6兔單克隆抗體100ul支1000
Bcl-6
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# BX50284?Clone# ?BP6261
Predicted?Molecular Wt:
79kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P41182
Background:
Bcl-6?is a transcriptional?regulator gene which codes for?a?706-amino-acid?nuclear?zinc finger?protein.The?mitogen-activated?protein?kinases,?Erk1 and?Erk2,?but?not?JNK,?phosphorylate?BCL6 at?multiple?sites.?Phosphorylation?of?BCL6?at?Ser333?and
Ser343?results?in?degradation?of?BCL6?by?the?ubiquitin/proteasome?pathway?in?B?cells.?In?addition,?BCL6?is?acetylated?and?its transcriptional?repressor function?is?inhibited?by the transcriptional co-activator?p300.
Antibodies to this?protein stain the germinal center?cells?in?lymphoid follicles,?follicular?cells?and?interfollicular?cells?in
Follicular?Lymphoma,?Diffuse?Large?B-Cell?Lymphomas,?Burkitt’s?Lymphoma, and the?majority of the?Reed-Sternberg cells?in?Nodular?Lymphocyte-Predominant?Hodgkin’s?Disease.
Bcl-6 combined with CD10 can?be?used to?distinguish?follicular?lymphoma?from?other?lymphomas.?Bcl-6?combined?with?CD10?and?MUM1 can?be?used for the classification of?diffuse?large?B-cell?lymphoma.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?Bcl-6 was?used as?an?immunogen. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Shvarts, A. et?al.?(2002)?Genes?Dev?16,?681-6.
2. ?Bereshchenko,?O.R. et?al.?(2002)?Nat?Genet?32,?606-13.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin- embedded?sections)?analysis of ?human tonsil?labelling?Bcl-?6 with?BP6261.

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