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MDR-1兔單克隆抗體

MDR-1兔單克隆抗體

  • 價(jià)格￥1800
  • 規(guī)格100ul
  • 貨號(hào)HKZ150406
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150406MDR-1兔單克隆抗體100ul支1800
MDR-1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50283?Clone# ?BP6260
Predicted?Molecular Wt:
141kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P08183
Background:
MDR1/ABCB1?belongs to the?Mdr/Tap subfamily of the ATP-binding cassette transporter?superfamily.?Multidrug?resistance?1
(MDR1) serves as an efflux?pump for?xenobiotic?compounds?with?broad?substrate?specificity.?MDR1?substrates?include
therapeutic agents such as actinomycin?D,etoposide,?imatinib,?and?doxorubicin,?as well?as?endogenous?molecules?including?β-?amyloids, steroid?hormones,?lipids,?phospholipids, cholesterol, and cytokines.?Intracellular?MDR1?has?been?detected?in?the?ER,?vesicles, and?nuclear envelope, and?has?been associated?with?cell?trafficking?machinery.?Other?reported?functions?of?MDR1
include viral?resistance, cytokine trafficking, and?lipid?homeostasis?in the?peripheral and?central?nervous?system.
MDR1 expressed?in the?plasma?membrane of cells?in the?blood-brain,?blood-cerebral?spinal fluid,?or?blood-placenta?barriers????restricts the?permeability of drugs?into these organs from the?apical?or?serosal?side.?MDR1?is?also?expressed?in?normal?tissues?with excretory function such as?small?intestine,?liver,?and?kidney.
Research studies?have shown that?MDR1?reduces drug accumulation?in?cancer?cells,?allowing?the?development?of?drug?resistance.
Subcellular?location:
Membrane
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?Miller,?D.S. et?al.?(2008)?Pharmacol?Rev?60,?196-209.
2.?Jeannesson,?E. et?al.?(2009) Clin?Chim?Acta?403,?198-202.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-??embedded?sections)?analysis of human?breast?cancer?labelling?MDR-1 with?BP6260.

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