CTLA-4兔單克隆抗體

價格￥1800
規(guī)格100ul
貨號HKZ150333
單位支
品牌HaoKebio

產品介紹

產品參數(shù)

資料下載

品牌	商品編碼	商品名稱	規(guī)格	單位	單價
HaoKebio	HKZ150333	CTLA-4兔單克隆抗體	100ul	支	1800

CTLA-4
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50210?Clone# ?BP6187
Predicted?Molecular Wt:
25kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P16410
Background:
Cytotoxic T?lymphocyte-associated antigen-4?(CTLA-4)?is a?member of the CD28?superfamily?and?is?a?negative?regulator?of T
cell-mediated?immune?responses. CTLA-4 expression?is?induced on the surface?of T?cells?after?CD28?binding?and?activation,
and?is constitutively expressed on T-regulatory cells,?acting?as?an?immune?checkpoint?inhibitor,?downregulating T?cell?activity.
CTLA-4?primarily?inactivates T-cell activity?by competing with the CD28?costimulatory?molecule.?CD28?and?CTLA-4?share?the?identical?ligands?of?CD80 and?CD86?on?antigenpresenting?cells;?and?thus?CTLA-4?competes?with?CD28?function?in?T-cell
survival,?proliferation, and?recruitment.?In?particular, CTLA-4 down-modulates CD4+?helper T-cell?activity?and?enhances Treg??immunosuppressive functions. CTLA-4?has?been shown to?play a?role?in?human?diseases.?CTLA-4?acts?as?a?physiological?brake?on the activated?immune system?in order to?maintain?immune?homeostasis.?Several?suppressive?mechanisms for T-cell
functions?have?been attributed to CTLA-4.
Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide within?Human CTLA-4.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Buchbinder?EI,?McDermott?DF.?Clinical?Therapeutics.?2015;?37:755-63.
2.?Scalapino?KJ,?Daikh?DI.?Immunol?Rev.?2008 Jun;223:143-55.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis
of ?human??tonsil?tissue?labelling?CTLA-4?with
BP6187.?Heat?mediated antigen?retrieval?was
performed?using
Tris/EDTA?buffer?pH?9.0

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