一抗 抗體 試劑 CTLA-4兔單克隆抗體一抗 抗體 試劑 價(jià)格¥1800規(guī)格100ul貨號(hào)HKZ150333單位支品牌HaoKebio QQ53383090 咨詢購(gòu)買 產(chǎn)品介紹產(chǎn)品參數(shù)資料下載 品牌商品編碼商品名稱規(guī)格單位單價(jià)HaoKebioHKZ150333CTLA-4兔單克隆抗體100ul支1800CTLA-4Recombinant?Rabbit?Monoclonal Antibody?Product?DatasheetCatalog# ?BX50210?Clone# ?BP6187Predicted?Molecular Wt:25kDaPurity: ??ProA?affinity?purified?IgGSpecies Cross-reactivity:HumanForm: ??LiquidApplications:IHC-PSwissprot?ID: ??P16410Background:Cytotoxic T?lymphocyte-associated antigen-4?(CTLA-4)?is a?member of the CD28?superfamily?and?is?a?negative?regulator?of Tcell-mediated?immune?responses. CTLA-4 expression?is?induced on the surface?of T?cells?after?CD28?binding?and?activation,and?is constitutively expressed on T-regulatory cells,?acting?as?an?immune?checkpoint?inhibitor,?downregulating T?cell?activity.CTLA-4?primarily?inactivates T-cell activity?by competing with the CD28?costimulatory?molecule.?CD28?and?CTLA-4?share?the?identical?ligands?of?CD80 and?CD86?on?antigenpresenting?cells;?and?thus?CTLA-4?competes?with?CD28?function?in?T-cellsurvival,?proliferation, and?recruitment.?In?particular, CTLA-4 down-modulates CD4+?helper T-cell?activity?and?enhances Treg??immunosuppressive functions. CTLA-4?has?been shown to?play a?role?in?human?diseases.?CTLA-4?acts?as?a?physiological?brake?on the activated?immune system?in order to?maintain?immune?homeostasis.?Several?suppressive?mechanisms for T-cellfunctions?have?been attributed to CTLA-4.Subcellular?location:MembraneRecommended?method:Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.Immunogen:Synthetic?peptide within?Human CTLA-4.Storage?Buffer:PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.Storage conditions:-25°C?to?-18°CStorage instructions:Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.Recommended?Dilutions:IHC-P:?????1:100-1:200Background?References:1. ?Buchbinder?EI,?McDermott?DF.?Clinical?Therapeutics.?2015;?37:755-63.2.?Scalapino?KJ,?Daikh?DI.?Immunol?Rev.?2008 Jun;223:143-55.Immunohistochemistry?(Formalin/PFA-fixedparaffin-embeddedsections)?analysisof ?human??tonsil?tissue?labelling?CTLA-4?withBP6187.?Heat?mediated antigen?retrieval?wasperformed?usingTris/EDTA?buffer?pH?9.0 HKZ150333_BP6187_CTLA-4下載 暫無(wú) 說(shuō)明文檔下載說(shuō)明書.pdf 上一篇: TPO鼠單克隆抗體下一篇: Growth Hormones鼠單克隆抗體 推薦 抗TNFAIP3的抗體 2020年11月17日 966 產(chǎn)品名稱 描述 查看全文 BAX鼠單克隆抗體 2023年7月14日 922 Tested Applications: FC, IHC, WB,ELISA Cited Applications: CoIP, IF, IHC, WB Species Specificity: hum... 查看全文 PMSF(100mM) 2023年7月11日 915 操作說(shuō)明 1.?本產(chǎn)品濃度為PMSF 100 mM,建議工作液終濃度為1 mM。 2. 使用前5分鐘,按每毫升蛋白裂解液中加10微升本產(chǎn)品的比例配制... 查看全文 c -Myc兔單克隆抗體 2024年5月23日 1017 暫無(wú) 查看全文 您好!請(qǐng)登錄 點(diǎn)擊取消回復(fù) 請(qǐng)登錄后評(píng)論 點(diǎn)擊這里取消回復(fù)。
BAX鼠單克隆抗體 2023年7月14日 922 Tested Applications: FC, IHC, WB,ELISA Cited Applications: CoIP, IF, IHC, WB Species Specificity: hum... 查看全文
PMSF(100mM) 2023年7月11日 915 操作說(shuō)明 1.?本產(chǎn)品濃度為PMSF 100 mM,建議工作液終濃度為1 mM。 2. 使用前5分鐘,按每毫升蛋白裂解液中加10微升本產(chǎn)品的比例配制... 查看全文
您好!請(qǐng)登錄