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CD8兔單克隆抗體

CD8兔單克隆抗體

  • 價格￥600
  • 規(guī)格100ul
  • 貨號HKZ150159
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150159CD8兔單克隆抗體100ul支600
CD8
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?BX50036?Clone# ?BP6041
?
Predicted?Molecular Wt:
26kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P01732
Background:
The CD8 antigen?is a cell?surface?glycoprotein found?on?most?cytotoxic T?lymphocytes ?that?serves?as?a?coreceptor?for?TCR????recognition of?MHC class?I–associated?peptides ?and supports?CTL?activation?by?binding?to?the?MHC,?while?making?no?direct?contact with the?peptide.
?
CD8?is?expressed?on?cytotoxic?suppressor?T?cells.?It?is?expressed?as?a?heterodimer?of?CD8α?and?CD8β?.?CD8?is?expressed?on approximately one-third of?peripheral?blood T cells?(the CD4-negative?cells).?CD8?has?also?been?detected?at?a?low?level?on?some?natural?killer?(NK) cells.?In?normal?human tonsil,?large?numbers of CD8+?lymphocytes were?present within?the
paracortex; occasionally?positive cells were also?identified within germinal?centers?and?within?the?investing?squamous?epithelium.?In other tissues, only?lymphoid cells and?cells?of?histiocyte?lineage?showed?positive?staining?for?CD8.
Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to CD8α?residues
within?aa135-235 of?CD8α was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Williamson?SL, et.al, Am?J?Pathol.?1998?Jun;152(6):1421-6.
2.?dela?Calle-Martin?O,?et.al, J?Clin?Invest.?2001?Jul;108(1):117-23.
Immunohistochemistry?(Formalin/PFA-fixedparaffin-embedded
sections analysis?of tonsil?tissue?labelling?CD8 with??BP6041.?Heat?mediated ???antigen?retrieval was
performed?using
Tris/EDTA?buffer?pH?9.0

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