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CD79a兔單克隆抗體

CD79a兔單克隆抗體

  • 價格￥600
  • 規(guī)格100ul
  • 貨號HKZ150158
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150158CD79a兔單克隆抗體100ul支600
CD79a
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
?
Catalog# ?BX50035?Clone# ?BP6040
?
Predicted?Molecular Wt:
25kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P11912
Background:
Cluster of differentiation CD79a also?known?as?B-cell?antigen?receptor?complex-associated?protein?alpha?chain?is?a?protein that
in?humans?is?encoded?by?the?CD79A?gene. The?CD79a?protein?together?with?the?related?CD79b?protein,?forms?a?dimer ??associated with?membrane-bound?immunoglobulin?in?B-cells, thus forming the?B-cell antigen?receptor?(BCR),and?plays?multiple and diverse?roles?in?B cell development?and?function.
?
CD79a?protein?is expressed?in virtually all?mature and?immature?B?cells and?the?majority?of?B-cell?neoplasms,?including
precursor?B–acute?lymphocytic?leukemia?(pre-B–ALL),?L and?H?lymphocyte?predominance?Hodgkin’s?lymphoma, and?many?plasma cell?tumors.
?
Therefore, antibodies to CD79a are?useful?in the?differential?diagnosis?of?B-cell?neoplasms from?T-cell?neoplasms?or?myeloid????neoplasms, or?L and?H?lymphocyte?predominance?Hodgkin’s?lymphoma from classic?Hodgkin’s?lymphoma.?In?addition,?CD79a?is a?useful?marker?in the diagnosis of?precursor?B–acute?lymphoblastic?leukemia?(pre-B–ALL)?because?many of these?tumors????are?negative?for?other?B-cell?markers, such?as?CD20?and?CD45RA.
Subcellular?location:
Membrane
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to CD79a?residues?????within?aa1-100 of?CD79a?was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Seda?V, et.al,?Eur?J?Haematol.?2015?Mar;94(3):193-205.
2.?Chu?PG, et.al,Appl?Immunohistochem?Mol?Morphol.
2001 Jun;9(2):97-106.
Immunohistochemistry?(Formalin/PFA-fixedparaffin-embedded
sections analysis?of tonsil?tissue?labelling?CD79a
with?BP6040.?Heat mediated?antigen
retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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