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MYD88 L265P兔單克隆抗體

MYD88 L265P兔單克隆抗體

  • 價格￥2200
  • 規(guī)格100ul
  • 貨號HKZ150388
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150388MYD88 L265P兔單克隆抗體100ul支2200
MYD88?L265P
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50265?Clone# ?BP6242
Predicted?Molecular Wt:
33kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q99836
Background:
Myeloid?differentiation factor 88?(MYD88), a?primary differentiation?response gene?in?Myeloid?precursors,?was?discovered?in?1990s. ?MYD88?is?a?universal?connexin?containing?three?main?structures:?N-terminal?death?domain?(DD),?intermediate
connexin domain?(ID), and C-terminal Toll/?interleukin-1?receptor?domain?(TIR). ?After?ligand?binding,?the?cytoplasmic TIR?domain?of?toll-like?receptor?(TLR) or?IL1R?binds?to?TIR?of?MYD88.
The?most?common?point?mutation?in?MYD88 is?the?replacement?of?leucine?(Leu) with?proline?(Pro) at?site?265,?known?as?the MYD88?L265P?mutation. ?A?recurrent?MYD88?L265P?mutation?was?first?identified?in?diffuse?Large?B-cell?lymphoma?(DLBCL).
This?mutation?is?rare or absent?in?PATIENTS with?CMB-DLBCL,?primary?mediastinal?B-cell?lymphoma, and?Burkitt’s?lymphoma.
Macroglobulinemia of?Fahrenheit?(WM)/lymphoplasmacytic?lymphoma?(LPL)?is an?indolant?non-Hodgkin’s?lymphoma with a?low?clinical?incidence. ?MyD88?L265P?mutation?is?accounted?for?87%?of?WM.
Subcellular?location:
Cytoplasmic
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Vu?N.?Ngo,et?al.?Nature.?2011?February?3; 470(7332):?115–119.
2.?Xose?S.?Puente, et?al.?Nature.?2011 JULY?7;?475:?110–?115.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-
embedded?sections)?analysis of ?overexpressed?MYD88????L265P?HEK293 cells?labelling?MYD88?L265P?with?BP6242.

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