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Procalc itonin兔單克隆抗體

Procalc itonin兔單克隆抗體

  • 價(jià)格￥2200
  • 規(guī)格100ul
  • 貨號(hào)HKZ150383
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150383Procalc itonin兔單克隆抗體100ul支2200
Procalcitonin
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50260?Clone# ?BP6237
Predicted?Molecular Wt:
13kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P01258
Background:
Procalcitonin?(PCT)?is?a?116 amino?acid?residue?peptide?with?molecular?weight?of?about?13?kDa.?PCT?itself?has?no?known
hormonal activity.?PCT?belongs to a group of?related?proteins?including?calcitonin?gene-related?peptides?I?and?II,?amylin,
adrenomodulin and calcitonin?(CAPA?peptide family).?PCT,?like other?peptides of?CAPA?family,?appears?from?the?common
precursor?pre-procalcitonin consisting of?141 amino acids?by?removal?of?25?amino?acids?from the?N-terminus.?PCT?undergoes?successive?cleavages?to?form?three?molecules:?N-terminal?fragment?(55 a.a.), calcitonin?(32?a.a.)?and?katacalcin?(21?a.a.).
Under?normal?metabolic conditions,?PCT?is only?present?in the C cells?of the?thyroid?gland.?In?bacterial?infection?and?sepsis,?however,?intact?PCT?is found?in the?blood and,?more?importantly,?its?level?is?related to the severity?of?bacterial?sepsis.
Nowadays,?PCT?is considered to?be one of the earliest?and?most?specific?markers?of?sepsis.
Subcellular?location:
Cytoplasm
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
A synthetic?peptide corresponding to the?N-term of?Procalcitonin was?used as an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?Kremmer?E??etal. Anal?Bioanal?Chem?402:989-95?(2012).
2. ?Llewelyn?MJ, et?al. J?Antimicrob?Chemother?2022?Feb 08.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-?embedded?sections)?analysis of C cells?of thyroid
labelling?Procalcitonin?with?BP6237.

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