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- 價格￥1000
- 規(guī)格100ul
- 貨號HKZ150265
- 單位支
- 品牌HaoKebio
產(chǎn)品介紹
產(chǎn)品參數(shù)
資料下載
| 品牌 | 商品編碼 | 商品名稱 | 規(guī)格 | 單位 | 單價 |
|---|
| HaoKebio | HKZ150265 | MSH2鼠單克隆抗體 | 100ul | 支 | 1000 |
|---|
MSH2
Mouse?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50142???Clone# ?BPM6143
Predicted?Molecular Wt:
105kDa
Purity: ??ProG?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P43246
Background:
MSH2?is?a?105?kDa?nuclear?antigen?and?encodes?a?protein?of?934?amino?acids. The?MSH2?antibody?gene?is?one?of?only?4?known?to encode?proteins?involved?in the?repair of?mismatch?nucleotides following?DNA?replication or?repair.?Mutations?in the?MSH2 gene??contribute to the development of sporadic colorectal?carcinoma.?MSHS?mutations?are?responsible?for?50%?of?hereditary?non-
polyposis colorectal cancer?(HNPCC). The?repair of?mismatch?DNA?is essential to?maintaining?the?integrity?of?genetic?information?overtime. An alteration of?microsatellite?repeats?is the?result of slippage?owing?to?strand?misalignment?during?DNA?replication????and?is?referred to as?microsatellite?instability?(MSI). These defects?in?DNA?repair?pathways?have?been?related to?human
carcinogenesis.?MSH-2?is?involved?in the?initial cognition of?mismatch?nucleotides during the?replication?mismatch?repair?process.??It?is thought that after?MSH2?binds to a?mismatched?DNA duplex?it?is joined?by?a?heterodimer?of?MLH1?and?PMSH,?which?together?help facilitate the?later steps?in?mismatch?repair.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer
(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)
for?30?minutes.
Immunogen:
Recombinant?fragment?(around?aa?327-427) of?human
MSH2?protein
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA
0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store
at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Thibodeau?SN,?French?AJ, et?al.Cancer?Res?1996?Nov
1;56(21):4836-40
2. ?National Committee for Clinical?Laboratory Standards?(NCCLS). Villanova,?PA?1991;7(9). Order?code?M29-P.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of
human colon?carcinoma
tissue from?Lynch disease
labelling?MSH2 with
BPM6143.?Heat?mediated antigen?retrieval?was
performed?using Tris/EDTA
buffer?pH?9.0
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