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Estrogen Receptor (ER) α兔單克隆抗體

Estrogen Receptor (ER) α兔單克隆抗體

  • 價格￥1400
  • 規(guī)格100ul
  • 貨號HKZ150258
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150258Estrogen Receptor (ER) α兔單克隆抗體100ul支1400
Estrogen?Receptor?(ER)?α
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50135?Clone# ?BP6139
Predicted?Molecular Wt:
66kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P03372
Background:
Estrogen?receptor?(ER)?belongs to the?steroid?receptor superfamily of?nuclear?receptors.?It?is?a?protein with?553?amino?acids.?The?receptor?molecule?has three domains,?i.e. the central?DNA-binding domain, the?hormone-binding?domain?at?the?C-
terminal, and the transcription-activating domain at the?N-terminal.?ER?mediates?regulatory?functions?of female?sex?steroids,???mainly?17?(E2), on growth, differentiation and function?in?several?target?tissues,?including?female?and?male?reproductive?tract,?mammary gland, and skeletal and?cardiovascular?systems.
Studies?have shown?ER α?is?present?in the?nuclei of epithelial?cells?in?normal?breast?and?endometrial?tissues,?as?well?as?a?subset?of?breast carcinomas.
Studies with?immunohistochemical assay show that?positive steroid?hormone status?has?predicted?favourable?overall,?survival,?independently of?hormonal treatment. Secondly,?ER α can?be?used?as?a?tumour?marker,?preferentially?in?combination?with?an???antibody to?progesterone?receptor,e.g.,?in the classification of adenocarcinomas.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?ER alpha?residues
within?aa495‐595 of?ER?alpha?was?used?as?an immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Stein?B, et.al,?Mol?Cell?Biol.?1995 Sep;15(9):4971-9.
2.?Saville?B, et.al,J?Biol?Chem.?2000?Feb?25;275(8):5379-87.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of
breast?carcinoma tissue?labelling?Estrogen
Receptor?(ER) α?with
BP6139.?Heat?mediated antigen?retrieval was
performed?using
Tris/EDTA?buffer?pH?9.0

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