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MUM1兔單克隆抗體

MUM1兔單克隆抗體

  • 價(jià)格￥1000
  • 規(guī)格100ul
  • 貨號(hào)HKZ150212
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150212MUM1兔單克隆抗體100ul支1000
MUM1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50089?Clone# ?BP6094
Predicted?Molecular Wt:
52kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q15306
Background:
MUM1?is one of?nuclear transcription factors?necessary for development?and?activation?of?B?lymphocytes.?MUM1?belongs?to?the?IRF gene family containing at?least?10 widely?expressed?genes with?similar?DNA?binding?motif?all?involved?in?regulation?of?cell growth, transformation and?induction of apoptosis?as well?as?development?of T-cell?immune?response. The?synonym?of????MUM1?is?Interferon?Regulatory?Factor?4?(IRF4)?.
MUM1?is found?mainly?in?B-cell?lymphoma and?melanocytic?lesions. Significant variation?in?positivity?mainly due to?chromosomal translocations?involving?MUM1 gene among T-cell?lymphomas?is observed.
MUM1?is?useful?in a?panel with other?markers for subclassification?of?malignant?lymphomas?and?identification?of?plasma?cell?differentiation.?Particularly?MUM1?may?be?useful for the?identification of?plasma cell differentiation?when?morphologic
evidence?is?lacking and?Ig?light chains are difficult?to?interpret.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?residues within C-?Term of?MUM1 was?used as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Grossman?A?,?Hans-Willi?Mittrücker,?Nicholl?J?, et?al.?Genomics,?1996, 37(2):0-233.
2.?Gaidano?G?, Carbone?A?.?LEUKEMIA,?2000,?14(4):563-?566.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of
diffuse?large?B cell
lymphoma?labelling
MUM1 with?BP6094.
Heat?mediated?antigen???retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0

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