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TIGIT兔單克隆抗體

TIGIT兔單克隆抗體

  • 價(jià)格￥2200
  • 規(guī)格100ul
  • 貨號(hào)HKZ150418
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150418TIGIT兔單克隆抗體100ul支2200
TIGIT
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50295?Clone# ?BP6272
Predicted?Molecular Wt:
26kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q495A1
Background:
T-cell?immunoreceptor with?Ig and?ITIM domains?(TIGIT), also?known?as VSIG9,?VSTM3,?and?WUCAM,?is?a?member?of the
poliovirus?receptor family of immunoglobulin?proteins. TIGIT?marks exhausted T?cells?in?the tumor?microenvironment?and?????during?human?immunodeficiency virus?(HIV)?infection.?Research?has shown TIGIT?interacts with several?receptors expressed?on antigen?presenting cells, such as?dendritic?cells?and?macrophages,?as?well?as tumor?cells?and?cells?of?the
microenvironment. TIGIT?binds?with?high?affinity?to?PVR/CD155, and?with?low?affinity?to?Nectin-2/CD112?and?Nectin-3/CD113.
TIGIT?is expressed at?low?levels on subsetsofT?cells and?NK?cells,?and?is?upregulated?at?the?protein?level?following?activation?of these?cells.
Subcellular?location:
Membrane
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?human TIGIT was
used as an?immunogen. This?information?is?proprietary?to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?Levin, S.D. et?al.?(2011)?Eur?J?Immunol?41,?902-15.
2.?Chauvin, J.M. et?al.?(2015) J?Clin?Invest?125,?2046-58.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded?sections)?analysis?of??human?tonsil?labelling?TIGIT?with?BP6272.

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