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- 價格￥1000
- 規(guī)格100ul
- 貨號HKZ150405
- 單位支
- 品牌HaoKebio
產(chǎn)品介紹
產(chǎn)品參數(shù)
資料下載
| 品牌 | 商品編碼 | 商品名稱 | 規(guī)格 | 單位 | 單價 |
|---|
| HaoKebio | HKZ150405 | Surviv in兔單克隆抗體 | 100ul | 支 | 1000 |
|---|
Survivin
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50282?Clone# ?BP6259
Predicted?Molecular Wt:
16kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??O15392
Background:
Survivin?is a?16?kDa anti-apoptotic?protein?highly expressed during?fetal?development?and?cancer?cell?malignancy.?Survivin?binds and?inhibits caspase-3, controlling the checkpoint?in?the?G2/M-phase?of the?cell?cycle?by?inhibiting?apoptosis?and
promoting cell division. This?regulatory?process?requires the?phosphorylation?of survivin?at?Thr34?by?p34?cdc2?kinase.?Gene???targeting?using a Thr34?phosphorylation-defective survivin?mutant, as well?as?antisense survivin,?have?been?shown?to?inhibit?tumor growth.
Survivin?is expressed?in tonsil, testis, fetal?tissue and?all?kinds?of tumors.?Survivin?is?not thought?to?be?expressed?in?adult
terminally?differentiated cells,?but?recent evidence?has also shown?expression?on?adult?vascular?endothelial?cells, T?cells,?red?blood cells, and?hematopoietic?progenitor?cells.
Survivin?is?mainly?used?in the diagnosis of?hepatocellular carcinoma, endometrial?carcinoma?and?squamous?cell?carcinoma.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Olie,?R.A. et?al.?(2000) Cancer?Res.?60,?2805-2809.
2.?Grossman,?D. et?al.?(2001)?Proc.?Natl. Acad. Sci.?USA?98,?635-640.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-????embedded?sections)?analysis of ?human tonsil?labelling?Survivin?with?BP6259.
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