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STAT6兔單克隆抗體

STAT6兔單克隆抗體

  • 價(jià)格￥1400
  • 規(guī)格100ul
  • 貨號(hào)HKZ150392
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150392STAT6兔單克隆抗體100ul支1400
STAT6
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50269?Clone# ?BP6246
Predicted?Molecular Wt:
94kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P42226
Background:
STAT6,a?member of the signal transducers and activators?of transcription?(STAT)?family,?has?been?found?to?form?recurrent
fusions with?NAB2 on chromosome?12q13?in the?majority of?solitary?fibrous tumors.?Inactivated?STAT6?can?be?found?in?the
form of a dimer?located?in the cytoplasm. The?fusion?of?STAT6?and?NAB2?enables?cytosolic?STAT6?to?migrate?to?the?nucleus
and thus allowing for detection?in?immunohistochemical assays.?NAB2-STAT6 fusion?transcriptions?have?been?reported?in?the?majority of solitary fibrous tumors?but?not?in?meningiomas,?hemangioblastomas, schwannomas, and?hemangiomas.
This?makes STAT6 a?useful?marker?in distinguishing solitary fibrous tumors?from?other?morphologically?similar?tumors.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1.?Gao?J??et?al.?Stem?Cell?ResTher?10:259?(2019).
2.?Cao?W??etal. J?Cell?Mol?Med?23:7029-7042?(2019).
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-?????embedded?sections)?analysis of ?human solitary?fibrous?tumor(SFT) ??labelling?STAT6?with?BP6246.

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