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Pan -TRK兔單克隆抗體

Pan -TRK兔單克隆抗體

  • 價(jià)格￥2200
  • 規(guī)格100ul
  • 貨號(hào)HKZ150356
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150356Pan -TRK兔單克隆抗體100ul支2200
pan-TRK
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50233?Clone# ?BP6210
Predicted?Molecular Wt:
92kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q16620
Background:
pan-TRK,?Full?name?of?NTRK:?Neurotrophic?Receptor?Kinase.?NTRK?gene?includes?three?subtypes:?NTRK1,?NTRK2 and?NTRK3,??which are?located on different chromosomes.The?proteins?encoded?by?NTRK?are?called?TRK?proteins,?and?NTRK1,?NTRK2?and
NTRK3 encode TRKA, TRKB and TRKC?respectively.TRK?protein?is a type?of?receptor tyrosine?kinase that?contains?the
extracellular?ligand-binding?region, the transmembrane?region, and the?intracellular?kinase?region.When TRK?binds to the?ligand, dimerization occurs, and?intracellular tyrosine?kinase?phosphorylation, signaling?downstream.
Three TRKs?proteins are?rarely expressed outside?nervous tissues,?but the?activation?of three TRK?receptor?structures?by?fusion?of three genesis considered to?bean oncogenic factor?(oncogene)?in the?pancancerous species.
NTRK gene fusion?mutation?is caused?by the fusion of?NTRK?gene family?members?(NTRK1,?NTRK2?and?NTRK3)?with?another?unrelated gene?(usually?housekeeping gene). ??The encoded TRK fusion?protein?is?in a?structurally?activated?state,?which
triggers a continuous signal cascade?reaction,?drives the?malignant?proliferation?of?cells,?and?causes?cancer.
Subcellular?location:
Cytoplasm
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?residues within?aa350-450 of?FOXP1 was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?-18?°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ??Br?i??I,?et?al.?Mod.?Pathol.?2020 Aug?28.
2.???Zhao?M, et?al.?Histopathology?2020 Jun?26.
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-?????embedded?sections)?analysis of?brain?labelling?pan-TRK?with?BP6210.

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