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c -Myc兔單克隆抗體

c -Myc兔單克隆抗體

  • 價(jià)格￥1000
  • 規(guī)格100ul
  • 貨號(hào)HKZ150341
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150341c -Myc兔單克隆抗體100ul支1000
c-Myc
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50218?Clone# ?BP6195
Predicted?Molecular Wt:
48kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P01106
Background:
Oncogene-encoded?proteins c-Myc,?n-Myc, and?l-Myc function?in cell?proliferation,?differentation?and?neoplastic?disease. A?mutated version of?Myc?is found?in?many cancers, which?causes?Myc to?be?constitutively?expressed. This?leads?to?the
unregulated expression of?many genes, some?of which?are?involved?in?cell?proliferation,?and?result?in?the?formation?of?cancer.?c-Myc?is a transcription factor and?is a?proto-oncogene that?is?the?focal?point?in?cell?cycle?regulation,?metabolism,?apoptosis,????differentiation, cell adhesion, and tumorigenesis.
A common?human translocation?involving?Mycist(8;14), which?is criticialto the development?of?most?cases?of?Burkitt’s?Lymphoma.?Malfunctions?in?Myc?have also?been found?in carcinoma of the?cervix,?colon,?breast,?lung,?and?stomach.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide?residues?in?human c-Myc was?used?as an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.??Hoffman?B, et?al. Oncogene.?2002;?21(21):3414-21.
2. ?Nakles?R, et?al.?Mol?Endocrinol.?2011;?25:549-63.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded?sections)?analysis?????of?human?Burkitt’s
lymphoma tissue?labelling??c-Myc?with?BP6195.?Heat ???mediated?antigen?retrieval?was?performed?using
Tris/EDTA?buffer?pH?9.0

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