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SMAD4兔單克隆抗體

SMAD4兔單克隆抗體

  • 價格￥2200
  • 規(guī)格100ul
  • 貨號HKZ150365
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150365SMAD4兔單克隆抗體100ul支2200
SMAD?4
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50242?Clone# ?BP6219
Predicted?Molecular Wt:
60kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q13485
Background:
SMAD 4?Plays a central?role?in the?balance?between atrophy?and?hypertrophy,?also?acts?synergistically?with?SMAD1?and?YY1?in?bone?morphogenetic?protein?(BMP)-mediated cardiac-specific gene expression.?It’s a component?of?the?heterotrimeric
SMAD2/SMAD3-SMAD4 complex that forms?in the?nucleus and?is?required for the TGF-mediated?signaling?and?promotes?binding?of?the?SMAD2/SMAD4/FAST-1 complex?to?DNA.
SMAD 4 shows cytoplasmic and?nuclear expression?in?most?tissues.
Alterations?in the SMAD4 gene was?primarily discovered?in?pancreatic?cancer?(duct?adenocarcinoma)?but?occur?in?a variety?of?cancers such as colorectal cancer, gastric?cancer,?prostate?cancer,?melanomas,?head?and?neck?cancers?and?many?others.?Loss??of SMAD4 expression?in tumors?has also?been shown?to?affect?cancer?progression?and?therapy,?such?as?reduced?response to????adjuvant chemotherapy.
Subcellular?location:
Nucleus/Cytoplasm
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Full?length?protein corresponding to?Human SMAD 4.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?Liu?F.,?Pouponnot?C.,?Massague?J.Genes?Dev.?11:3157-?3167(1997)
2.?Seong?H.A., Jung?H.,?Kim?K.T.,?Ha?H.J.?Biol. Chem.282:12272-12289(2007)
Immunohistochemistry?analysis of?Human?pancreatic ductal?carcinoma?labelling?SMAD4 with?BP6219.

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