Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20oC storage. Immunogen Information
Full name: apoptosis-inducing factor, mitochondrion-associated, 1
Calculated molecular weight: 609 aa, 66 kDa
Observed molecular weight: 67 kDa, 57 kDa
Gene symbol AIFM1
Synonyms AIF, AIFM1, PDCD8 Background Apoptosis-inducing factor (AIF) is one of the mitochondrial proteins to be released into the cytosol during apoptosis, and it is discovered as the first protein that regulates caspase-independent apoptosis(PMID:20494118). AIF is encoded as a 67 kDa protein that contains a mitochondrial localization signal (MLS) in the N-terminus.It is cleaved from the 62 kDa to the 57 kDa form following ischemic injury and translocated from the mitochondria to the nucleus in a calpain-dependent manner(PMID:19332058).
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