\n
\n![\"PRAME\u5154\u5355\u514b\u9686\u6297\u4f53\"\/](\"https:\/\/www.haokebio.com\/wp-content\/themes\/smartenterprise\/images\/loading.png\")
<\/a><\/div><\/div>
![\"PRAME\u5154\u5355\u514b\u9686\u6297\u4f53\"\/](\"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241018100452334.png?imageView2\/0\/format\/webp\/q\/75\")
<\/a><\/div><\/div>\nPRAME\u5154\u5355\u514b\u9686\u6297\u4f53<\/h1><\/div>
PRAME\u5154\u5355\u514b\u9686\u6297\u4f53<\/h1><\/div><\/i>\u4e00\u6297<\/a> \u6297\u4f53<\/a> \u8bd5\u5242<\/a> <\/span><\/div><\/header>- \u4ef7\u683c<\/span>\u00a52200<\/span><\/li>
- \u89c4\u683c<\/span>100ul<\/span><\/li>
- \u8d27\u53f7<\/span>HKZ150394<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/th> \u89c4\u683c<\/strong><\/th> \u5355\u4f4d<\/strong><\/th> \u5355\u4ef7<\/strong><\/th><\/tr> HaoKebio<\/th> HKZ150394<\/th> PRAME\u5154\u5355\u514b\u9686\u6297\u4f53<\/th> 100ul<\/th> \u652f<\/th> 2200<\/th><\/tr><\/tbody><\/table>PRAME<\/strong>
Recombinant\u00a0Rabbit\u00a0Monoclonal Antibody\u00a0Product\u00a0Datasheet<\/strong>
Catalog# \u00a0<\/strong>BX50271\u00a0Clone# \u00a0<\/strong>BP6248
Predicted\u00a0Molecular Wt:<\/strong>
58kDa
Purity: \u00a0\u00a0<\/strong>ProA\u00a0affinity\u00a0purified\u00a0IgG
Species Cross-reactivity:<\/strong>
Human
Form: \u00a0\u00a0<\/strong>Liquid
Applications:<\/strong>
IHC-P
Swissprot\u00a0ID: \u00a0\u00a0<\/strong>P78395
Background:<\/strong>
Cancer\/testis antigens\u00a0(CTAs) area family of\u00a0more than\u00a0100\u00a0proteins whose\u00a0normal\u00a0expression\u00a0is\u00a0largely\u00a0restricted\u00a0to\u00a0immune\u00a0privileged germ cells of the testis, ovary,\u00a0and trophoblast\u00a0cells\u00a0of the\u00a0placenta.\u00a0Although\u00a0most\u00a0normal\u00a0somatic\u00a0tissues\u00a0are\u00a0void\u00a0of CTA expression, due to epigenetic\u00a0silencing\u00a0of gene\u00a0expression,\u00a0their\u00a0expression\u00a0is\u00a0upregulated\u00a0in\u00a0a\u00a0wide\u00a0variety\u00a0of\u00a0human\u00a0\u00a0\u00a0solid and\u00a0liquid tumors.
PRAME\u00a0(preferentially expressed antigen\u00a0in\u00a0melanoma)\u00a0is a cancer\/testis\u00a0antigen\u00a0not\u00a0normally\u00a0expressed\u00a0in\u00a0any\u00a0tissues\u00a0except\u00a0testis,\u00a0but\u00a0is\u00a0upregulated\u00a0in tumors.\u00a0PRAME\u00a0is expressed\u00a0in\u00a0melanoma cells and\u00a0is\u00a0recognized\u00a0by\u00a0cytolytic T-cells.\u00a0It\u00a0is\u00a0also
upregulated\u00a0in other diseases, such as\u00a0synovial\u00a0sarcoma,\u00a0NSCLC,\u00a0and\u00a0breast\u00a0cancer,\u00a0where\u00a0it\u00a0is\u00a0thought\u00a0to\u00a0contribute\u00a0to
tumorigenesis and\u00a0metastasis.\u00a0PRAME\u00a0is also\u00a0highly expressed\u00a0in\u00a0liquid tumors such\u00a0as\u00a0AML\u00a0and\u00a0can\u00a0be\u00a0predictive\u00a0of\u00a0clinical\u00a0outcome\u00a0in some circumstances.
PRAME and other cancer\/testis antigens\u00a0are\u00a0currently\u00a0being\u00a0pursued\u00a0as\u00a0novel\u00a0immunotherapy\u00a0targets\u00a0and\u00a0diagnostic\u00a0biomarkers.
Subcellular\u00a0location:<\/strong>
Nucleus
Recommended\u00a0Method:<\/strong>
Heat\u00a0induced epitope\u00a0retrieval with Tris-EDTA\u00a0buffer\u00a0\u00a0\u00a0(pH\u00a09.0),\u00a0primary\u00a0antibody\u00a0incubate\u00a0at\u00a0RT\u00a0(18\u00b0C-25\u00b0C)\u00a0for\u00a030\u00a0minutes.
Immunogen:<\/strong>
Recombinant\u00a0protein fragment of\u00a0human\u00a0PRAME was\u00a0used as\u00a0an\u00a0immunogen.
Storage\u00a0Buffer:<\/strong>
PBS\u00a059%, Sodium\u00a0azide\u00a00.01%,\u00a0Glycerol\u00a040%,\u00a0BSA 0.05%.
Storage Conditions:<\/strong>
-25\u00b0C\u00a0to\u00a0-18\u00b0C
Shipment\u00a0Instructions:<\/strong>
Shipped\u00a0on\u00a0blue\u00a0ice.\u00a0Upon\u00a0delivery\u00a0store\u00a0at\u00a0-25\u00b0C\u00a0to\u00a0-18\u00a0\u00b0C. Avoid\u00a0freeze\u00a0\/ thaw\u00a0cycles.
Recommended\u00a0Dilution:<\/strong>
IHC-P:\u00a0\u00a0\u00a0\u00a0\u00a01:100-1:200
Background\u00a0References:<\/strong>
1.\u00a0Qin, Y.Z.\u00a0et\u00a0al.\u00a0(2017) Oncol\u00a0Lett\u00a013,\u00a02823-2830.
2. \u00a0Iura,\u00a0K.\u00a0et\u00a0al.\u00a0(2017)\u00a0Hum\u00a0Pathol\u00a061,\u00a0130-139.
Immunohistochemistry\u00a0(Formalin\/PFA-fixed\u00a0paraffin-\u00a0embedded\u00a0sections)\u00a0analysis of \u00a0human
malignant\u00a0melanoma\u00a0labelling\u00a0PRAME\u00a0with\u00a0BP6248.<\/figcaption><\/figure>\n\n\n\nHKZ150394_BP6248_PRAME<\/a>\u4e0b\u8f7d<\/a><\/div>\n<\/div>\n\n\n\n\n<\/p>\n\n\n\n
\n\n<\/p>\n<\/div>\n<\/div>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n<\/div>\n\n\n\n
\n\u6682\u65e0<\/p>\n\n\n\n
\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul><\/div><\/section>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>
<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":11735,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false,"footnotes":""},"categories":[101,99,98],"tags":[],"class_list":["post-6189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yk","category-kt","category-products"],"metadata":{"_wp_page_template":["default"],"_wpcom_metas":["a:1:{s:11:\"show_indent\";s:1:\"0\";}"],"views":["954"],"_canshu":["a:5:{i:0;a:5:{s:5:\"title\";s:6:\"\u4ef7\u683c\";s:4:\"text\";s:6:\"\u00a52200\";s:2:\"f1\";i:16;s:2:\"f2\";s:7:\"#e21f2f\";s:2:\"f3\";b:1;}i:1;a:5:{s:5:\"title\";s:6:\"\u89c4\u683c\";s:4:\"text\";s:5:\"100ul\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:2;a:5:{s:5:\"title\";s:6:\"\u8d27\u53f7\";s:4:\"text\";s:9:\"HKZ150394\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:3;a:5:{s:5:\"title\";s:6:\"\u5355\u4f4d\";s:4:\"text\";s:3:\"\u652f\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";b:0;}i:4;a:5:{s:5:\"title\";s:6:\"\u54c1\u724c\";s:4:\"text\";s:8:\"HaoKebio\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}}"],"catce":["sidebar-widgets4"],"_thumbnail_id":["11735"],"_dp_original":["6187"],"_edit_lock":["1732345607:2"],"_edit_last":["2"]},"medium_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241018100452334.png","thumbnail_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241018100452334-251x193.png","full_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241018100452334.png","_links":{"self":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/6189"}],"collection":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/comments?post=6189"}],"version-history":[{"count":7,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/6189\/revisions"}],"predecessor-version":[{"id":12826,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/6189\/revisions\/12826"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media\/11735"}],"wp:attachment":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media?parent=6189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/categories?post=6189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/tags?post=6189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- \u4ef7\u683c<\/span>\u00a52200<\/span><\/li>
- \u89c4\u683c<\/span>100ul<\/span><\/li>
- \u8d27\u53f7<\/span>HKZ150394<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/th> \u89c4\u683c<\/strong><\/th> \u5355\u4f4d<\/strong><\/th> \u5355\u4ef7<\/strong><\/th><\/tr> HaoKebio<\/th> HKZ150394<\/th> PRAME\u5154\u5355\u514b\u9686\u6297\u4f53<\/th> 100ul<\/th> \u652f<\/th> 2200<\/th><\/tr><\/tbody><\/table> PRAME<\/strong>
Recombinant\u00a0Rabbit\u00a0Monoclonal Antibody\u00a0Product\u00a0Datasheet<\/strong>
Catalog# \u00a0<\/strong>BX50271\u00a0Clone# \u00a0<\/strong>BP6248
Predicted\u00a0Molecular Wt:<\/strong>
58kDa
Purity: \u00a0\u00a0<\/strong>ProA\u00a0affinity\u00a0purified\u00a0IgG
Species Cross-reactivity:<\/strong>
Human
Form: \u00a0\u00a0<\/strong>Liquid
Applications:<\/strong>
IHC-P
Swissprot\u00a0ID: \u00a0\u00a0<\/strong>P78395
Background:<\/strong>
Cancer\/testis antigens\u00a0(CTAs) area family of\u00a0more than\u00a0100\u00a0proteins whose\u00a0normal\u00a0expression\u00a0is\u00a0largely\u00a0restricted\u00a0to\u00a0immune\u00a0privileged germ cells of the testis, ovary,\u00a0and trophoblast\u00a0cells\u00a0of the\u00a0placenta.\u00a0Although\u00a0most\u00a0normal\u00a0somatic\u00a0tissues\u00a0are\u00a0void\u00a0of CTA expression, due to epigenetic\u00a0silencing\u00a0of gene\u00a0expression,\u00a0their\u00a0expression\u00a0is\u00a0upregulated\u00a0in\u00a0a\u00a0wide\u00a0variety\u00a0of\u00a0human\u00a0\u00a0\u00a0solid and\u00a0liquid tumors.
PRAME\u00a0(preferentially expressed antigen\u00a0in\u00a0melanoma)\u00a0is a cancer\/testis\u00a0antigen\u00a0not\u00a0normally\u00a0expressed\u00a0in\u00a0any\u00a0tissues\u00a0except\u00a0testis,\u00a0but\u00a0is\u00a0upregulated\u00a0in tumors.\u00a0PRAME\u00a0is expressed\u00a0in\u00a0melanoma cells and\u00a0is\u00a0recognized\u00a0by\u00a0cytolytic T-cells.\u00a0It\u00a0is\u00a0also
upregulated\u00a0in other diseases, such as\u00a0synovial\u00a0sarcoma,\u00a0NSCLC,\u00a0and\u00a0breast\u00a0cancer,\u00a0where\u00a0it\u00a0is\u00a0thought\u00a0to\u00a0contribute\u00a0to
tumorigenesis and\u00a0metastasis.\u00a0PRAME\u00a0is also\u00a0highly expressed\u00a0in\u00a0liquid tumors such\u00a0as\u00a0AML\u00a0and\u00a0can\u00a0be\u00a0predictive\u00a0of\u00a0clinical\u00a0outcome\u00a0in some circumstances.
PRAME and other cancer\/testis antigens\u00a0are\u00a0currently\u00a0being\u00a0pursued\u00a0as\u00a0novel\u00a0immunotherapy\u00a0targets\u00a0and\u00a0diagnostic\u00a0biomarkers.
Subcellular\u00a0location:<\/strong>
Nucleus
Recommended\u00a0Method:<\/strong>
Heat\u00a0induced epitope\u00a0retrieval with Tris-EDTA\u00a0buffer\u00a0\u00a0\u00a0(pH\u00a09.0),\u00a0primary\u00a0antibody\u00a0incubate\u00a0at\u00a0RT\u00a0(18\u00b0C-25\u00b0C)\u00a0for\u00a030\u00a0minutes.
Immunogen:<\/strong>
Recombinant\u00a0protein fragment of\u00a0human\u00a0PRAME was\u00a0used as\u00a0an\u00a0immunogen.
Storage\u00a0Buffer:<\/strong>
PBS\u00a059%, Sodium\u00a0azide\u00a00.01%,\u00a0Glycerol\u00a040%,\u00a0BSA 0.05%.
Storage Conditions:<\/strong>
-25\u00b0C\u00a0to\u00a0-18\u00b0C
Shipment\u00a0Instructions:<\/strong>
Shipped\u00a0on\u00a0blue\u00a0ice.\u00a0Upon\u00a0delivery\u00a0store\u00a0at\u00a0-25\u00b0C\u00a0to\u00a0-18\u00a0\u00b0C. Avoid\u00a0freeze\u00a0\/ thaw\u00a0cycles.
Recommended\u00a0Dilution:<\/strong>
IHC-P:\u00a0\u00a0\u00a0\u00a0\u00a01:100-1:200
Background\u00a0References:<\/strong>
1.\u00a0Qin, Y.Z.\u00a0et\u00a0al.\u00a0(2017) Oncol\u00a0Lett\u00a013,\u00a02823-2830.
2. \u00a0Iura,\u00a0K.\u00a0et\u00a0al.\u00a0(2017)\u00a0Hum\u00a0Pathol\u00a061,\u00a0130-139.
Immunohistochemistry\u00a0(Formalin\/PFA-fixed\u00a0paraffin-\u00a0embedded\u00a0sections)\u00a0analysis of \u00a0human
malignant\u00a0melanoma\u00a0labelling\u00a0PRAME\u00a0with\u00a0BP6248.<\/figcaption><\/figure>\n\n\n\nHKZ150394_BP6248_PRAME<\/a>\u4e0b\u8f7d<\/a><\/div>\n<\/div>\n\n\n\n\n<\/p>\n\n\n\n
\n\n<\/p>\n<\/div>\n<\/div>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n<\/div>\n\n\n\n
\n\u6682\u65e0<\/p>\n\n\n\n
\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>
- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul><\/div><\/section>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>
<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":11735,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false,"footnotes":""},"categories":[101,99,98],"tags":[],"class_list":["post-6189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yk","category-kt","category-products"],"metadata":{"_wp_page_template":["default"],"_wpcom_metas":["a:1:{s:11:\"show_indent\";s:1:\"0\";}"],"views":["954"],"_canshu":["a:5:{i:0;a:5:{s:5:\"title\";s:6:\"\u4ef7\u683c\";s:4:\"text\";s:6:\"\u00a52200\";s:2:\"f1\";i:16;s:2:\"f2\";s:7:\"#e21f2f\";s:2:\"f3\";b:1;}i:1;a:5:{s:5:\"title\";s:6:\"\u89c4\u683c\";s:4:\"text\";s:5:\"100ul\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:2;a:5:{s:5:\"title\";s:6:\"\u8d27\u53f7\";s:4:\"text\";s:9:\"HKZ150394\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:3;a:5:{s:5:\"title\";s:6:\"\u5355\u4f4d\";s:4:\"text\";s:3:\"\u652f\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";b:0;}i:4;a:5:{s:5:\"title\";s:6:\"\u54c1\u724c\";s:4:\"text\";s:8:\"HaoKebio\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}}"],"catce":["sidebar-widgets4"],"_thumbnail_id":["11735"],"_dp_original":["6187"],"_edit_lock":["1732345607:2"],"_edit_last":["2"]},"medium_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241018100452334.png","thumbnail_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241018100452334-251x193.png","full_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241018100452334.png","_links":{"self":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/6189"}],"collection":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/comments?post=6189"}],"version-history":[{"count":7,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/6189\/revisions"}],"predecessor-version":[{"id":12826,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/6189\/revisions\/12826"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media\/11735"}],"wp:attachment":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media?parent=6189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/categories?post=6189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/tags?post=6189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul>