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\n![\"HER2\u5154\u5355\u514b\u9686\u6297\u4f53\"\/](\"https:\/\/www.haokebio.com\/wp-content\/themes\/smartenterprise\/images\/loading.png\")
<\/a><\/div><\/div>
![\"HER2\u5154\u5355\u514b\u9686\u6297\u4f53\"\/](\"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241015163445170.png?imageView2\/0\/format\/webp\/q\/75\")
<\/a><\/div><\/div>\nHER2\u5154\u5355\u514b\u9686\u6297\u4f53<\/h1><\/div>
HER2\u5154\u5355\u514b\u9686\u6297\u4f53<\/h1><\/div><\/i>\u4e00\u6297<\/a> \u6297\u4f53<\/a> \u8bd5\u5242<\/a> <\/span><\/div><\/header>- \u4ef7\u683c<\/span>\uffe51000<\/span><\/li>
- \u89c4\u683c<\/span>100ul<\/span><\/li>
- \u8d27\u53f7<\/span>HKZ150138<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/th> \u89c4\u683c<\/strong><\/th> \u5355\u4f4d<\/strong><\/th> \u5355\u4ef7<\/strong><\/th><\/tr> HaoKebio<\/th> HKZ150138<\/th> HER2\u5154\u5355\u514b\u9686\u6297\u4f53<\/th> 100ul<\/th> \u652f<\/th> 1000<\/th><\/tr><\/tbody><\/table>HER-2<\/strong>
Recombinant\u00a0Rabbit\u00a0Monoclonal Antibody\u00a0Product\u00a0Datasheet<\/strong>
\u00a0
Catalog# \u00a0<\/strong>BX50015\u00a0Clone# \u00a0<\/strong>BP6020
\u00a0
Predicted\u00a0Molecular Wt:<\/strong>
138kDa
Purity: \u00a0\u00a0<\/strong>ProA\u00a0affinity\u00a0purified\u00a0IgG
Species Cross-reactivity:<\/strong>
Human
Form: \u00a0\u00a0<\/strong>Liquid
Applications:<\/strong>
IHC-P
Swissprot\u00a0ID: \u00a0\u00a0<\/strong>P04626
![](\"file:\/\/\/C:\\Users\\22512\\AppData\\Local\\Temp\\ksohtml1824\\wps1.png\")
Background:<\/strong>
HER-2\u00a0(also\u00a0called\u00a0HER-2\/neu, c-erbB2,\u00a0ERBB2 or\u00a0neu)\u00a0is\u00a0a\u00a0transmembrane\u00a0receptor\u00a0tyrosine\u00a0kinase,\u00a0which\u00a0is\u00a0a\u00a0proto-\u00a0\u00a0\u00a0oncogene,\u00a0i.e.\u00a0its activation causes\u00a0malignant transformation and\u00a0increases the\u00a0malignant\u00a0potential\u00a0(cell\u00a0proliferation,
invasiveness etc.) of the cells.\u00a0In\u00a0human cancers\u00a0HER-2\u00a0is\u00a0activated\u00a0via\u00a0gene\u00a0amplification,\u00a0which\u00a0is\u00a0a\u00a0genomic\u00a0mutation\u00a0where\u00a0a\u00a0small\u00a0fragment\u00a0at\u00a0chromosome\u00a0band\u00a017q12-q21\u00a0is\u00a0multiplied\u00a0in\u00a0a\u00a0cell\u00a0up\u00a0to\u00a050-100\u00a0folds.
\u00a0
HER-2\u00a0is\u00a0over-expressed\u00a0in\u00a015-25% of\u00a0primary\u00a0breast\u00a0cancers, can\u00a0also\u00a0be\u00a0found\u00a0in\u00a0intestinal\u00a0type\u00a0gastric\u00a0and\u00a0gastroesophageal carcinomas, ovarian carcinomas,\u00a0high grade endometrial\u00a0carcinomas\u00a0and\u00a0some salivary\u00a0duct\u00a0tumors.\u00a0Low-level\u00a0copy\u00a0number\u00a0\u00a0\u00a0\u00a0\u00a0increases\u00a0have\u00a0been found also\u00a0in\u00a0rare cases of\u00a0lung tumors.
\u00a0
Studies\u00a0have shown that c-erbB-2\u00a0positive\u00a0breast cancer\u00a0usually correlates\u00a0with\u00a0negative\u00a0staining\u00a0for\u00a0estrogen\u00a0and\u00a0progesterone\u00a0receptors; thus a\u00a0poorer\u00a0predictive outcome\u00a0is correlated with\u00a0positive\u00a0c-erbB-2\u00a0staining.
\u00a0
Subcellular\u00a0location:<\/strong>
Membrane
Recommended\u00a0method:<\/strong>
Heat\u00a0induced epitope\u00a0retrieval with Tris-EDTA\u00a0buffer\u00a0\u00a0\u00a0(pH\u00a09.0),\u00a0primary\u00a0antibody\u00a0incubate\u00a0at\u00a0RT\u00a0(18\u00b0C-25\u00b0C)\u00a0for\u00a030\u00a0minutes.
Immunogen:<\/strong>
Synthetic\u00a0peptide\u00a0according\u00a0to\u00a0the\u00a0aa1155-1255\u00a0(C-\u00a0terminal) of \u00a0HER-2\u00a0was\u00a0used\u00a0as\u00a0an\u00a0immunogen.
Storage\u00a0Buffer:<\/strong>
PBS\u00a059%, Sodium\u00a0azide\u00a00.01%,\u00a0Glycerol\u00a040%,\u00a0BSA 0.05%.
Storage conditions:<\/strong>
-25\u00b0C\u00a0to\u00a0-18\u00b0C
Storage instructions:<\/strong>
Shipped on\u00a0blue\u00a0ice.\u00a0Upon delivery,\u00a0aliquot,\u00a0and\u00a0store\u00a0at\u00a0-25\u00b0C\u00a0to\u00a0-18\u00b0C. Avoid\u00a0freeze\u00a0\/\u00a0thaw\u00a0cycles.
Recommended\u00a0Dilutions:<\/strong>
IHC-P:\u00a0\u00a0\u00a0\u00a0\u00a01:100-1:200
Immunohistochemistry
(Formalin\/PFA-fixed
paraffin-embedded
sections)\u00a0analysis of
human\u00a0breast cancer
tissue\u00a0labelling\u00a0HER-2 with\u00a0BP6020.\u00a0Heat\u00a0mediated
antigen\u00a0retrieval was\u00a0performed\u00a0using
Tris\/EDTA\u00a0buffer\u00a0pH\u00a09.0
Background\u00a0References:<\/strong>
1.\u00a0Olayioye\u00a0M.A., et.al. Chem.\u00a0274:17209-17218(1999).
2.\u00a0Wang\u00a0S.C., et.al. Cancer\u00a0Cell\u00a06:251-261(2004).<\/figcaption><\/figure>\n\n\n\nHKZ150138_BP6020_HER2<\/a>\u4e0b\u8f7d<\/a><\/div>\n<\/div>\n\n\n\n\n<\/p>\n\n\n\n
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\n\u6682\u65e0<\/p>\n\n\n\n
\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul><\/div><\/section>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>
<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":11222,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false,"footnotes":""},"categories":[101,99,98],"tags":[],"class_list":["post-5407","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yk","category-kt","category-products"],"metadata":{"_wp_page_template":["default"],"_wpcom_metas":["a:1:{s:11:\"show_indent\";s:1:\"0\";}"],"views":["1038"],"_canshu":["a:5:{i:0;a:5:{s:5:\"title\";s:6:\"\u4ef7\u683c\";s:4:\"text\";s:7:\"\uffe51000\";s:2:\"f1\";i:16;s:2:\"f2\";s:7:\"#e21f2f\";s:2:\"f3\";b:1;}i:1;a:5:{s:5:\"title\";s:6:\"\u89c4\u683c\";s:4:\"text\";s:5:\"100ul\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:2;a:5:{s:5:\"title\";s:6:\"\u8d27\u53f7\";s:4:\"text\";s:9:\"HKZ150138\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:3;a:5:{s:5:\"title\";s:6:\"\u5355\u4f4d\";s:4:\"text\";s:3:\"\u652f\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";b:0;}i:4;a:5:{s:5:\"title\";s:6:\"\u54c1\u724c\";s:4:\"text\";s:8:\"HaoKebio\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}}"],"catce":["sidebar-widgets4"],"_dp_original":["5405"],"_edit_lock":["1731988535:2"],"_edit_last":["2"],"_thumbnail_id":["11222"]},"medium_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241015163445170-300x258.png","thumbnail_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241015163445170-251x193.png","full_url":"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/20241015163445170.png","_links":{"self":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/5407"}],"collection":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/comments?post=5407"}],"version-history":[{"count":10,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/5407\/revisions"}],"predecessor-version":[{"id":12347,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/5407\/revisions\/12347"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media\/11222"}],"wp:attachment":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media?parent=5407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/categories?post=5407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/tags?post=5407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- \u4ef7\u683c<\/span>\uffe51000<\/span><\/li>
- \u89c4\u683c<\/span>100ul<\/span><\/li>
- \u8d27\u53f7<\/span>HKZ150138<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/th> \u89c4\u683c<\/strong><\/th> \u5355\u4f4d<\/strong><\/th> \u5355\u4ef7<\/strong><\/th><\/tr> HaoKebio<\/th> HKZ150138<\/th> HER2\u5154\u5355\u514b\u9686\u6297\u4f53<\/th> 100ul<\/th> \u652f<\/th> 1000<\/th><\/tr><\/tbody><\/table> HER-2<\/strong>
Recombinant\u00a0Rabbit\u00a0Monoclonal Antibody\u00a0Product\u00a0Datasheet<\/strong>
\u00a0
Catalog# \u00a0<\/strong>BX50015\u00a0Clone# \u00a0<\/strong>BP6020
\u00a0
Predicted\u00a0Molecular Wt:<\/strong>
138kDa
Purity: \u00a0\u00a0<\/strong>ProA\u00a0affinity\u00a0purified\u00a0IgG
Species Cross-reactivity:<\/strong>
Human
Form: \u00a0\u00a0<\/strong>Liquid
Applications:<\/strong>
IHC-P
Swissprot\u00a0ID: \u00a0\u00a0<\/strong>P04626
Background:<\/strong>
HER-2\u00a0(also\u00a0called\u00a0HER-2\/neu, c-erbB2,\u00a0ERBB2 or\u00a0neu)\u00a0is\u00a0a\u00a0transmembrane\u00a0receptor\u00a0tyrosine\u00a0kinase,\u00a0which\u00a0is\u00a0a\u00a0proto-\u00a0\u00a0\u00a0oncogene,\u00a0i.e.\u00a0its activation causes\u00a0malignant transformation and\u00a0increases the\u00a0malignant\u00a0potential\u00a0(cell\u00a0proliferation,
invasiveness etc.) of the cells.\u00a0In\u00a0human cancers\u00a0HER-2\u00a0is\u00a0activated\u00a0via\u00a0gene\u00a0amplification,\u00a0which\u00a0is\u00a0a\u00a0genomic\u00a0mutation\u00a0where\u00a0a\u00a0small\u00a0fragment\u00a0at\u00a0chromosome\u00a0band\u00a017q12-q21\u00a0is\u00a0multiplied\u00a0in\u00a0a\u00a0cell\u00a0up\u00a0to\u00a050-100\u00a0folds.
\u00a0
HER-2\u00a0is\u00a0over-expressed\u00a0in\u00a015-25% of\u00a0primary\u00a0breast\u00a0cancers, can\u00a0also\u00a0be\u00a0found\u00a0in\u00a0intestinal\u00a0type\u00a0gastric\u00a0and\u00a0gastroesophageal carcinomas, ovarian carcinomas,\u00a0high grade endometrial\u00a0carcinomas\u00a0and\u00a0some salivary\u00a0duct\u00a0tumors.\u00a0Low-level\u00a0copy\u00a0number\u00a0\u00a0\u00a0\u00a0\u00a0increases\u00a0have\u00a0been found also\u00a0in\u00a0rare cases of\u00a0lung tumors.
\u00a0
Studies\u00a0have shown that c-erbB-2\u00a0positive\u00a0breast cancer\u00a0usually correlates\u00a0with\u00a0negative\u00a0staining\u00a0for\u00a0estrogen\u00a0and\u00a0progesterone\u00a0receptors; thus a\u00a0poorer\u00a0predictive outcome\u00a0is correlated with\u00a0positive\u00a0c-erbB-2\u00a0staining.
\u00a0
Subcellular\u00a0location:<\/strong>
Membrane
Recommended\u00a0method:<\/strong>
Heat\u00a0induced epitope\u00a0retrieval with Tris-EDTA\u00a0buffer\u00a0\u00a0\u00a0(pH\u00a09.0),\u00a0primary\u00a0antibody\u00a0incubate\u00a0at\u00a0RT\u00a0(18\u00b0C-25\u00b0C)\u00a0for\u00a030\u00a0minutes.
Immunogen:<\/strong>
Synthetic\u00a0peptide\u00a0according\u00a0to\u00a0the\u00a0aa1155-1255\u00a0(C-\u00a0terminal) of \u00a0HER-2\u00a0was\u00a0used\u00a0as\u00a0an\u00a0immunogen.
Storage\u00a0Buffer:<\/strong>
PBS\u00a059%, Sodium\u00a0azide\u00a00.01%,\u00a0Glycerol\u00a040%,\u00a0BSA 0.05%.
Storage conditions:<\/strong>
-25\u00b0C\u00a0to\u00a0-18\u00b0C
Storage instructions:<\/strong>
Shipped on\u00a0blue\u00a0ice.\u00a0Upon delivery,\u00a0aliquot,\u00a0and\u00a0store\u00a0at\u00a0-25\u00b0C\u00a0to\u00a0-18\u00b0C. Avoid\u00a0freeze\u00a0\/\u00a0thaw\u00a0cycles.
Recommended\u00a0Dilutions:<\/strong>
IHC-P:\u00a0\u00a0\u00a0\u00a0\u00a01:100-1:200
Immunohistochemistry
(Formalin\/PFA-fixed
paraffin-embedded
sections)\u00a0analysis of
human\u00a0breast cancer
tissue\u00a0labelling\u00a0HER-2 with\u00a0BP6020.\u00a0Heat\u00a0mediated
antigen\u00a0retrieval was\u00a0performed\u00a0using
Tris\/EDTA\u00a0buffer\u00a0pH\u00a09.0
Background\u00a0References:<\/strong>
1.\u00a0Olayioye\u00a0M.A., et.al. Chem.\u00a0274:17209-17218(1999).
2.\u00a0Wang\u00a0S.C., et.al. Cancer\u00a0Cell\u00a06:251-261(2004).<\/figcaption><\/figure>\n\n\n\nHKZ150138_BP6020_HER2<\/a>\u4e0b\u8f7d<\/a><\/div>\n<\/div>\n\n\n\n\n<\/p>\n\n\n\n
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\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>
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