![\"E-Cadherin\u5154\u5355\u514b\u9686\u6297\u4f53\"\/](\"https:\/\/www.haokebio.com\/wp-content\/uploads\/2024\/05\/444.jpg?imageView2\/0\/format\/webp\/q\/75\")
<\/a><\/div><\/div>E-Cadherin\u5154\u5355\u514b\u9686\u6297\u4f53<\/h1><\/div><\/i>\u4e00\u6297<\/a> \u6297\u4f53<\/a> \u8bd5\u5242<\/a> <\/span><\/div><\/header>- \u4ef7\u683c<\/span>\uffe51125<\/span><\/li>
- \u89c4\u683c<\/span>100ul<\/span><\/li>
- \u8d27\u53f7<\/span>HKI0391A<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/th> \u89c4\u683c<\/strong><\/th> \u5355\u4f4d<\/strong><\/th> \u5355\u4ef7<\/strong><\/th><\/tr> HaoKebio<\/th> HKI0391A<\/th> E-Cadherin\u5154\u5355\u514b\u9686\u6297\u4f53<\/th> 100ul<\/th> \u652f<\/th> 1125<\/th><\/tr><\/tbody><\/table><\/figure>\n\n\n\nApplications<\/h3>\n\n\n\n
Tested Applications:<\/strong><\/p>\n\n\n\n
FC, IF, IHC, WB,ELISA<\/p>\n\n\n\n
\n\n\n\nCited Applications:<\/strong><\/p>\n\n\n\n
FC, IF, IHC, WB<\/p>\n\n\n\n
Species Specificity:<\/strong><\/p>\n\n\n\n
human, pig, rat<\/p>\n\n\n\n
\n\n\n\nCited Species:<\/strong><\/p>\n\n\n\n
human, monkey, mouse, pig<\/p>\n\n\n\n
\n\n\n\nPositive WB detected in:<\/strong><\/p>\n\n\n\n
PC-3 cells, A431 cells, MCF-7 cells, pig brain tissue, MKN-45 cells, SGC-7901 cells<\/p>\n\n\n\n
\n\n\n\nPositive IHC detected in:<\/strong><\/p>\n\n\n\n
human breast cancer tissue, human colon tissue, rat colon tissue<\/p>\n\n\n\n
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0<\/em><\/strong><\/p>\n\n\n\n
\n\n\n\nPositive IF detected in:<\/strong><\/p>\n\n\n\n
human breast cancer tissue, human kidney tissue<\/p>\n\n\n\n
\n\n\n\nPositive FC detected in:<\/strong><\/p>\n\n\n\n
A431 cells<\/p>\n\n\n\n
\n\n\n\nRecommended dilution:<\/strong><\/p>\n\n\n\n
WB : 1:2000-1:8000<\/p>\n\n\n\n
IHC : 1:1000-1:4000<\/p>\n\n\n\n
IF : 1:200-1:800<\/p>\n\n\n\n
Product Information<\/h3>\n\n\n\n
\n\n\n\nSource:<\/strong><\/p>\n\n\n\n
Mouse<\/p>\n\n\n\n
\n\n\n\nPurification method:<\/strong><\/p>\n\n\n\n
Protein A purification<\/p>\n\n\n\n
\n\n\n\nIsotype:<\/strong><\/p>\n\n\n\n
IgG2b<\/p>\n\n\n\n
\n\n\n\nStorage:<\/strong><\/p>\n\n\n\n
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20\u00b0C. Stable for one year after shipment. Aliquoting is unnecessary for -20o<\/sup>C storage.<\/p>\n\n\n\n
\n\n\n\nFull name:<\/strong><\/p>\n\n\n\n
cadherin 1, type 1, E-cadherin (epithelial)<\/p>\n\n\n\n
\n\n\n\nCalculated molecular weight:<\/strong><\/p>\n\n\n\n
882 aa, 97 kDa<\/p>\n\n\n\n
\n\n\n\nObserved molecular weight:<\/strong><\/p>\n\n\n\n
120 kDa<\/p>\n\n\n\n
\n\n\n\n
\n\n\n\nGene symbol<\/strong><\/p>\n\n\n\n
CDH1<\/p>\n\n\n\n
\n\n\n\nSynonyms<\/strong><\/p>\n\n\n\n
Arc 1, Cadherin 1, CAM 120\/80, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, Epithelial cadherin, LCAM, UVO, Uvomorulin<\/p>\n\n\n\n
Background<\/h3>\n\n\n\nCadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120\/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, \u03b1-, \u03b2-, and \u03b3-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.<\/p>\n\n\n\n
Protocols<\/h3>\n<\/div>\n\n\n\n\n<\/p>\n\n\n\n
\n\n<\/p>\n<\/div>\n<\/div>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n<\/div>\n\n\n\n
\n\u6682\u65e0<\/p>\n\n\n\n
\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul><\/div><\/section>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>
<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":7870,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false,"footnotes":""},"categories":[101,99,98],"tags":[],"class_list":["post-4532","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yk","category-kt","category-products"],"metadata":{"_wp_page_template":["default"],"_wpcom_metas":["a:1:{s:11:\"show_indent\";s:1:\"0\";}"],"views":["1127"],"_canshu":["a:5:{i:0;a:5:{s:5:\"title\";s:6:\"\u4ef7\u683c\";s:4:\"text\";s:7:\"\uffe51125\";s:2:\"f1\";i:16;s:2:\"f2\";s:7:\"#e21f2f\";s:2:\"f3\";b:1;}i:1;a:5:{s:5:\"title\";s:6:\"\u89c4\u683c\";s:4:\"text\";s:5:\"100ul\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:2;a:5:{s:5:\"title\";s:6:\"\u8d27\u53f7\";s:4:\"text\";s:8:\"HKI0391A\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:3;a:5:{s:5:\"title\";s:6:\"\u5355\u4f4d\";s:4:\"text\";s:3:\"\u652f\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";b:0;}i:4;a:5:{s:5:\"title\";s:6:\"\u54c1\u724c\";s:4:\"text\";s:8:\"HaoKebio\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}}"],"catce":["sidebar-widgets4"],"_dp_original":["4529"],"_edit_lock":["1728531419:2"],"_edit_last":["2"],"_thumbnail_id":["7870"]},"medium_url":null,"thumbnail_url":null,"full_url":null,"_links":{"self":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/4532"}],"collection":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/comments?post=4532"}],"version-history":[{"count":5,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/4532\/revisions"}],"predecessor-version":[{"id":9557,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/4532\/revisions\/9557"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media?parent=4532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/categories?post=4532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/tags?post=4532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- \u4ef7\u683c<\/span>\uffe51125<\/span><\/li>
- \u89c4\u683c<\/span>100ul<\/span><\/li>
- \u8d27\u53f7<\/span>HKI0391A<\/span><\/li>
- \u5355\u4f4d<\/span>\u652f<\/span><\/li>
- \u54c1\u724c<\/span>HaoKebio<\/span><\/li><\/ul>\n\n\n\nQQ53383090 \u54a8\u8be2\u8d2d\u4e70<\/a><\/div>\n<\/div>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>
<\/div><\/div><\/section>\n\n\n\n<\/i>\u4ea7\u54c1\u4ecb\u7ecd<\/span><\/div><\/i>\u4ea7\u54c1\u53c2\u6570<\/span><\/div><\/i>\u8d44\u6599\u4e0b\u8f7d<\/span><\/div><\/div><\/div>\n\n\u54c1\u724c<\/strong><\/th> \u5546\u54c1\u7f16\u7801<\/strong><\/th> \u5546\u54c1\u540d\u79f0<\/strong><\/th> \u89c4\u683c<\/strong><\/th> \u5355\u4f4d<\/strong><\/th> \u5355\u4ef7<\/strong><\/th><\/tr> HaoKebio<\/th> HKI0391A<\/th> E-Cadherin\u5154\u5355\u514b\u9686\u6297\u4f53<\/th> 100ul<\/th> \u652f<\/th> 1125<\/th><\/tr><\/tbody><\/table><\/figure>\n\n\n\n Applications<\/h3>\n\n\n\n
Tested Applications:<\/strong><\/p>\n\n\n\n
FC, IF, IHC, WB,ELISA<\/p>\n\n\n\n
\n\n\n\nCited Applications:<\/strong><\/p>\n\n\n\n
FC, IF, IHC, WB<\/p>\n\n\n\n
Species Specificity:<\/strong><\/p>\n\n\n\n
human, pig, rat<\/p>\n\n\n\n
\n\n\n\nCited Species:<\/strong><\/p>\n\n\n\n
human, monkey, mouse, pig<\/p>\n\n\n\n
\n\n\n\nPositive WB detected in:<\/strong><\/p>\n\n\n\n
PC-3 cells, A431 cells, MCF-7 cells, pig brain tissue, MKN-45 cells, SGC-7901 cells<\/p>\n\n\n\n
\n\n\n\nPositive IHC detected in:<\/strong><\/p>\n\n\n\n
human breast cancer tissue, human colon tissue, rat colon tissue<\/p>\n\n\n\n
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0<\/em><\/strong><\/p>\n\n\n\n
\n\n\n\nPositive IF detected in:<\/strong><\/p>\n\n\n\n
human breast cancer tissue, human kidney tissue<\/p>\n\n\n\n
\n\n\n\nPositive FC detected in:<\/strong><\/p>\n\n\n\n
A431 cells<\/p>\n\n\n\n
\n\n\n\nRecommended dilution:<\/strong><\/p>\n\n\n\n
WB : 1:2000-1:8000<\/p>\n\n\n\n
IHC : 1:1000-1:4000<\/p>\n\n\n\n
IF : 1:200-1:800<\/p>\n\n\n\n
Product Information<\/h3>\n\n\n\n
\n\n\n\nSource:<\/strong><\/p>\n\n\n\n
Mouse<\/p>\n\n\n\n
\n\n\n\nPurification method:<\/strong><\/p>\n\n\n\n
Protein A purification<\/p>\n\n\n\n
\n\n\n\nIsotype:<\/strong><\/p>\n\n\n\n
IgG2b<\/p>\n\n\n\n
\n\n\n\nStorage:<\/strong><\/p>\n\n\n\n
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20\u00b0C. Stable for one year after shipment. Aliquoting is unnecessary for -20o<\/sup>C storage.<\/p>\n\n\n\n
\n\n\n\nFull name:<\/strong><\/p>\n\n\n\n
cadherin 1, type 1, E-cadherin (epithelial)<\/p>\n\n\n\n
\n\n\n\nCalculated molecular weight:<\/strong><\/p>\n\n\n\n
882 aa, 97 kDa<\/p>\n\n\n\n
\n\n\n\nObserved molecular weight:<\/strong><\/p>\n\n\n\n
120 kDa<\/p>\n\n\n\n
\n\n\n\n
\n\n\n\nGene symbol<\/strong><\/p>\n\n\n\n
CDH1<\/p>\n\n\n\n
\n\n\n\nSynonyms<\/strong><\/p>\n\n\n\n
Arc 1, Cadherin 1, CAM 120\/80, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, Epithelial cadherin, LCAM, UVO, Uvomorulin<\/p>\n\n\n\n
Background<\/h3>\n\n\n\n
Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. E-cadherin (epithelial cadherin), also known as CDH1 (cadherin 1) or CAM 120\/80, is a classical member of the cadherin superfamily which also include N-, P-, R-, and B-cadherins. It has been regarded as a marker for spermatogonial stem cells in mice(PMID:23509752). E-cadherin is expressed on the cell surface in most epithelial tissues. The extracellular region of E-cadherin establishes calcium-dependent homophilic trans binding, providing specific interaction with adjacent cells, while the cytoplasmic domain is connected to the actin cytoskeleton through the interaction with p120-, \u03b1-, \u03b2-, and \u03b3-catenin (plakoglobin). E-cadherin is important in the maintenance of the epithelial integrity, and is involved in mechanisms regulating proliferation, differentiation, and survival of epithelial cell. E-cadherin may also play a role in tumorigenesis. It is considered to be an invasion suppressor protein and its loss is an indicator of high tumor aggressiveness.<\/p>\n\n\n\n
Protocols<\/h3>\n<\/div>\n\n\n\n
\n<\/p>\n\n\n\n
\n\n<\/p>\n<\/div>\n<\/div>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n\n\n\n
<\/p>\n<\/div>\n\n\n\n
\n\u6682\u65e0<\/p>\n\n\n\n
\u8bf4\u660e\u6587\u6863\u4e0b\u8f7d<\/span><\/h3>
- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul><\/div><\/section>\n\n\n\n
<\/p>\n<\/div>\n<\/div><\/div>
<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":7870,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"themepark_post_bcolor":"#f5f5f5","themepark_post_width":"1022px","themepark_post_img":"","themepark_post_img_po":"left","themepark_post_img_re":false,"themepark_post_img_cover":false,"themepark_post_img_fixed":false,"themepark_post_hide_title":false,"themepark_post_main_b":"","themepark_post_main_p":100,"themepark_paddingblock":false,"footnotes":""},"categories":[101,99,98],"tags":[],"class_list":["post-4532","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-yk","category-kt","category-products"],"metadata":{"_wp_page_template":["default"],"_wpcom_metas":["a:1:{s:11:\"show_indent\";s:1:\"0\";}"],"views":["1127"],"_canshu":["a:5:{i:0;a:5:{s:5:\"title\";s:6:\"\u4ef7\u683c\";s:4:\"text\";s:7:\"\uffe51125\";s:2:\"f1\";i:16;s:2:\"f2\";s:7:\"#e21f2f\";s:2:\"f3\";b:1;}i:1;a:5:{s:5:\"title\";s:6:\"\u89c4\u683c\";s:4:\"text\";s:5:\"100ul\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:2;a:5:{s:5:\"title\";s:6:\"\u8d27\u53f7\";s:4:\"text\";s:8:\"HKI0391A\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}i:3;a:5:{s:5:\"title\";s:6:\"\u5355\u4f4d\";s:4:\"text\";s:3:\"\u652f\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";b:0;}i:4;a:5:{s:5:\"title\";s:6:\"\u54c1\u724c\";s:4:\"text\";s:8:\"HaoKebio\";s:2:\"f1\";s:0:\"\";s:2:\"f2\";s:0:\"\";s:2:\"f3\";s:0:\"\";}}"],"catce":["sidebar-widgets4"],"_dp_original":["4529"],"_edit_lock":["1728531419:2"],"_edit_last":["2"],"_thumbnail_id":["7870"]},"medium_url":null,"thumbnail_url":null,"full_url":null,"_links":{"self":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/4532"}],"collection":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/comments?post=4532"}],"version-history":[{"count":5,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/4532\/revisions"}],"predecessor-version":[{"id":9557,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/posts\/4532\/revisions\/9557"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/media?parent=4532"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/categories?post=4532"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.haokebio.com\/wp-json\/wp\/v2\/tags?post=4532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- <\/i><\/a>\u8bf4\u660e\u4e66.pdf<\/span><\/a><\/li><\/ul>