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EZH2兔單克隆抗體

EZH2兔單克隆抗體

  • 價格￥1400
  • 規(guī)格100ul
  • 貨號HKZ150415
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150415EZH2兔單克隆抗體100ul支1400
EZH2
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50292?Clone# ?BP6269
Predicted?Molecular Wt:
85kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID:??Q15910
Background:
EZH2?belongs?to?polycomb?group?(PcG). Catalytic?subunit?of?the?PRC2/EED-EZH2?complex, which?methylates’Lys-9′?(H3K9me)?and’Lys-27′?(H3K27me) of?histone?H3,?leading?to?transcriptional?repression?of?the?affected?target?gene.?EZH2?displays?a
preference for substrates with?less?methylation. The?PRC2/EED-EZH2 complex?may?also?serve?as?a?recruiting?platform?for?DNA?methyltransferases.
EZH2 expressed?in?many tissues.?In the ovary,?EZH2 expressed?in?primordial?follicles?and?oocytes?and?also?in?external?follicle?cells.?EZH2 overexpressed?in?numerous tumor types?including carcinomas of the?breast,?colon,?larynx,?lymphoma?and testis.
The?high expression of?EZH2?is closely?related to the?malignant?process,?invasiveness?and?metastasis?ability?of tumors.?EZH2?may?be a?new?marker and therapeutic target for?lymphoma.
Subcellular?location:
Nucleus
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of?EZH2 was?used as?an?immunogen. This?information?is?proprietary to?Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?PMID:?14532106
2. ?PMID: 31451685
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded?sections)?analysis?of??human?testis?labelling?EZH2 with?BP6269.

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