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Clusterin兔單克隆抗體

Clusterin兔單克隆抗體

  • 價格￥1400
  • 規(guī)格100ul
  • 貨號HKZ150414
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150414Clusterin兔單克隆抗體100ul支1400
Clusterin
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50291?Clone# ?BP6268
Predicted?Molecular Wt:
52kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P10909
Background:
Clusterin functions as extracellular chaperone that?prevents aggregation?of?nonnative?proteins.?It?also?functions?as
extracellular chaperone that?prevents aggregation of?nonnative?proteins.?It’s?intracellular form?suppresses stress-induced?apoptosis?by stabilizing?mitochondrial?membrane?integrity through?interaction with?HSPA5.
Clusterin?is detected?in?blood?plasma, cerebrospinal fluid,?milk, seminal?plasma?and?colon?mucosa.??It’s?also?detected?in?brain,?testis, ovary,?liver and?pancreas, and at?lower?levels?in?kidney,?heart,?spleen?and?lung.
Clusterin?has?been?shown?to?stain?95% of?systemic?ALCL,?including?100% of?ALK-1(+)?and?91% of?ALK-1(-)?ALCL. Studies?have shown that clusterin?may?be a?useful diagnostic?marker for ALCL,?especially?in?ALK-1(-)?cases.?Overexpression?of?clusterin
appears to?be a?useful?prognostic factor for?patients with ovarian?carcinomas.
Subcellular?location:
Secreted
Recommended?Method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment of Clusterin was?used?as an?immunogen. This?information?is?proprietary to??Biolynx.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage Conditions:
-25°C?to?-18°C
Shipment?Instructions:
Shipped?on?blue?ice.?Upon?delivery?store?at?-25°C?to?–?18°C. Avoid?freeze?/ thaw?cycles.
Recommended?Dilution:
IHC-P:?????1:100-1:200
Background?References:
1. ?PMID:11123922
2. ?PMID:17322305
Immunohistochemistry?(Formalin/PFA-fixed?paraffin-embedded????sections)?analysis?of??human?ALCL?labelling?Clusterin?with?BP6268.

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