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ATRX兔單克隆抗體

ATRX兔單克隆抗體

  • 價(jià)格￥1000
  • 規(guī)格100ul
  • 貨號(hào)HKZ150348
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150348ATRX兔單克隆抗體100ul支1000
ATRX
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50225?Clone# ?BP6202
Predicted?Molecular Wt:
283kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P46100
Background:
α-thalassemia/mental?retardation X-linked?(ATRX)?is a transcriptional?regulator and?helicase that?belongs to the?SNF2 family??of chromatin?remodeling?proteins. Together with?its?binding?partner death-associated?protein?6?(Daxx), ATRX acts?as?histone?chaperone to deposit?histone variant?H3.3 at?repetitive?DNA sequences such?as?telomeric,?pericentric,?and?ribosomal?gene?????repeats. ATRX?is?involved?in?many?nuclear functions that ensure?proper sister chromatid?cohesion?during?mitosis?and
chromosome alignment during?meiosis. The ATRX transcriptional?regulator also?plays?a?role?in?the?maintenance?of telomere???integrity and the?regulation of gene expression?during?mammalian?development?by?influencing?DNA?methylation?patterns?at?high?DNA?repeat sequences.?Mutations?in the corresponding ATRX gene?results?in ATR-X?syndrome,?an?X-linked?disorder
characterized?by?intellectual disabilities, craniofacial abnormalities, and?mild?α-thalassemia.
Subcellular?location:
Nuclear
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Recombinant?protein fragment within?Human ATRX.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Schwartzentruber, J. et?al.?(2012)?Nature?482,?226-31.
2. ?Els?sser, S.J. et?al.?(2012)?Nature?491,?560-5.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded?sections)?analysis of?human
breast?carcinoma tissue
labelling?ATRX?with?BP6202.?Heat?mediated?antigen
retrieval?was?performed????using Tris/EDTA?buffer?pH?9.0

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