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STAT6兔單克隆抗體

STAT6兔單克隆抗體

  • 價(jià)格￥1400
  • 規(guī)格100ul
  • 貨號(hào)HKZ150339
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150339STAT6兔單克隆抗體100ul支1400
STAT6
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50216?Clone# ?BP6193
Predicted?Molecular Wt:
94kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P42226
Background:
STAT6,a?member of the signal transducers and activators?of transcription?(STAT)?family,?has?been?found?to?form?recurrent
fusions with?NAB2 on chromosome?12q13?in the?majority of?solitary?fibrous tumors.?Inactivated?STAT6?can?be?found?in?the
form of a dimer?located?in the cytoplasm.?STAT6?and?NAB2?fusion?enables?cytosolic?STAT6?to?migrate?to?the?nucleus?and?thus?allowing for detection?in?immunohistochemical assays.?NAB2-STAT6 fusion transcriptions?have?been?reported?in the?majority??of solitary fibrous tumors?but?not?in?meningiomas,?hemangioblastomas, schwannomas, and?hemangiomas. This?makes STAT6?a?useful?marker?in distinguishing solitary fibrous tumors from other?morphologically?similar tumors.
Subcellular?location:
Nucleus/Cytoplasm
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide?residues?in?human STAT6 was?used?as an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Gao?J??et?al.?Stem?Cell?ResTher?10:259?(2019).
2.?Cao?W??etal. J?Cell?Mol?Med?23:7029-7042?(2019).
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of?human?solitary fibrous tumor(SFT)???tissue?labelling STAT6?with???BP6193.?Heat?mediated
antigen?retrieval?was
performed?using Tris/EDTA?buffer?pH?9.0

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