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IgD兔單克隆抗體

IgD兔單克隆抗體

  • 價(jià)格￥600
  • 規(guī)格100ul
  • 貨號(hào)HKZ150253
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150253IgD兔單克隆抗體100ul支600
IgD
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50130?Clone# ?BP6134
Predicted?Molecular Wt:
42kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P01880
Background:
Immunoglobulins are?produced?by cells of the?B-lymphocyte?lineage.?Based on?differences?in?the?heavy?chain,?five
immunoglobulin?isotypes are?known as?IgA,?IgG,?IgM,?IgDand?IgE.?Human?IgD exists?in two forms:?secreted?IgD?(secIgD),
present?in small amounts?in?human serum, and?membrane-bound?IgD?(mIgD),?present?on?the?surface?of?mature?B?cells.?MIgD?is co-expressed with?membrane-bound?IgM?(mIgM) and?plays a?major?role as?an?antigenic?receptor?on?the?surface?of?B-
lymphocytes.?IgD?is expressed?in?normal?and?neoplastic?mantle?B cells.?It?is absent?in?most cells?of?normal?splenic?marginal?zone?but?present?in?30% to?40% of?splenic?marginal?zone?lymphomas?(MZLs). Additionally,?IgD?may?be?a?marker?for?the
identification of?nodular?lymphocyte?predominant?hodgkin?lymphoma. Antibody to?IgD?is?useful for classification?of?B-cell?derived?lymphomas and?plasmacytomas.
Subcellular?location:
Cytoplasm
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?residues within???aa50-150 of?Human?IgD?was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Leong?AS,?et?al.,?Geenwich?Medical?Media?Ltd.?1999;?217-219.
2.?Arnold?A, et?al.,?New?Eng?J?Med?1983;?309:1593-1599.
Immunohistochemistry
(Formalin/PFA-fixed
paraffin-embedded
sections analysis?of
human ?tonsil ?tissue
labelling?IgD?with?BP6134.?Heat?mediated?antigen
retrieval?was?performed????using Tris/EDTA?buffer?pH?9.0

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