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TTF-1兔單克隆抗體

TTF-1兔單克隆抗體

  • 價格￥1000
  • 規(guī)格100ul
  • 貨號HKZ150197
  • 單位支
  • 品牌HaoKebio

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HaoKebioHKZ150197TTF-1兔單克隆抗體100ul支1000
TTF-1
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50074?Clone# ?BP6079
Predicted?Molecular Wt:
39kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P43699
Background:
Thyroid?transcription?factor-1?(synonymes:?Homeobox?protein?Nkx-2.1)?is?a?371 amino?acid?protein,?39?KDa,which?belongs?to ??the?NKX?homeobox transcription factor family. TTF-1 stimulate or?repress transcription?of?particular genes?by?binding?to?their????regulatory sequences. ??TTF-1?plays a?role?in?regulating genes?in the thyroid,?lung?and?brain.?Its?molecular targets?in?the?thyroid?gland are thyroglobulin, thyroperoxidase and thyrotropin?receptor. TTF-1 activates transcription?of the?genes?encoding?these????proteins.?In?lung, TTF-1?promotes the transcription of the surfactant?proteins A to?D,?and the?Clara?cell?secretory?protein.?In
brain, the?molecular targets of TTF-1 are?unknown.?Besides?being a tissue-specific?transcription?promoter?in?adult?organs, TTF-?1?has?been suggested a?role?in?morphogenesis and cytodifferentiation. Among?thyroid?neoplasms,?TTF1?is?seen?in?virtually?all????tumours of follicular derivation.
In diagnostic?pathology, TTF-1?is?useful as?marker for?pulmonary adenocarcinoma?and?pulmonary?neuroendocrine?malignancy,
including small cell?lung carcinoma.?It can?be?used?to?differentiate?primary?lung?adenocarcinoma?from?metastasis?of?extrapulmonary origin.
Subcellular?location:
Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?residues within?aa50-150 of??TTF-1 was?used?as?an?immunogen.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1.?Agoff?SN,?Lamps?LW,?Philip?AT, et?al.??Mod?Pathol 2000,13:238-242.
2. ?Bingle?CD.?Int?J?Biochem?Cell?Biol?1997;29:1471-1473.
Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded
sections)?analysis of
thyroid?labelling TTF-1?with?BP6079.?Heat
mediated?antigen
retrieval?was?performed?using Tris/EDTA?buffer????pH?9.0.

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