ERO1L兔多克隆抗體

價(jià)格￥1200
規(guī)格50ul
貨號(hào)HK210137S
單位支
品牌HaoKebio

產(chǎn)品介紹

產(chǎn)品參數(shù)

資料下載

品牌	商品編碼	商品名稱	規(guī)格	單位	單價(jià)
HaoKebio	HK210137S	ERO1L兔多克隆抗體	50ul	支	1200

Applications

Tested Applications:
FC, IHC, WB,ELISA

Cited Applications:
WB
Species Specificity:
human, mouse, rat

Cited Species:
mouse, pig

Positive WB detected in:
mouse ovary tissue, A431 cells

Positive IHC detected in:
human pancreas cancer tissue
Note: suggested antigen retrieval with?TE buffer pH 9.0;?(*) Alternatively, antigen retrieval may be performed with?citrate buffer pH 6.0

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:50-1:500
Product Information

Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment.?Aliquoting is unnecessary for -20^oC storage.
Immunogen Information

Full name:
ERO1-like (S. cerevisiae)

Calculated molecular weight:
468 aa, 54 kDa

Observed molecular weight:
54 kDa

Gene symbol
ERO1L

Synonyms
ERO1 alpha, ERO1 L, ERO1 L alpha, ERO1 like (S. cerevisiae), ERO1 like protein alpha, ERO1L, Oxidoreductin 1 L alpha
Background
ERO1L, also named as ERO1-alpha, is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. It is required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. This antibody has no cross reaction to ERO1.

暫無

說明文檔下載

說明書.pdf

上一篇: ERp19兔多克隆抗體下一篇: Cyclin D3兔多克隆抗體

普通病理

分子病理

成像分析

分子生物

理化檢測(cè)

蛋白生物學(xué)

細(xì)胞實(shí)驗(yàn)

普通形態(tài)

分子病理

分子生物學(xué)

抗體

蛋白質(zhì)生物學(xué)

ERO1L兔多克隆抗體

說明文檔下載

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